Effects of Miramistin and Phosprenil on Microbial Biofilms

Effects of Miramistin and Phosprenil on biofilms of S. pyogenes , S. aureus , E. coli , L. acidophilus , and L. plantarum were studied. Significant differences in the effects of these substances on mature biofilms of microorganisms and the process of their formation were observed. Miramistin had sig...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2017-08, Vol.163 (4), p.439-442
Main Authors: Danilova, T. A., Danilina, G. A., Adzhieva, A. A., Minko, A. G., Nikolaeva, T. N., Zhukhovitskii, V. G., Pronin, A. V.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Benzalkonium Compounds - pharmacology
Biofilms - drug effects
Biomedical and Life Sciences
Biomedicine
Cell Biology
Comparative analysis
Escherichia coli
Escherichia coli - drug effects
Immunology and Microbiology
Internal Medicine
Laboratory Medicine
Microbial Sensitivity Tests
Pathology
Staphylococcus aureus - drug effects
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Summary:Effects of Miramistin and Phosprenil on biofilms of S. pyogenes , S. aureus , E. coli , L. acidophilus , and L. plantarum were studied. Significant differences in the effects of these substances on mature biofilms of microorganisms and the process of their formation were observed. Miramistin had significant inhibiting effects on the forming of biofilms and on the formed biofilms of all studied microorganisms. Treatment with Miramistin inhibited biofilm formation by 2-3 times compared to the control. This effect was found already after using of Miramistin in the low doses (3.12 μg/ml). Inhibition of the growth of a formed biofilm was observed only after treatment with Miramistin in the high doses (25-50 μg/ml). Phosprenil in the high doses (15-30 mg/ml) inhibited the forming of biofilms, especially the biofilms of S. pyogenes and L. plantarum (by 3-4.5 times). Treatment of formed biofilms with the agent in doses of 6.0 and 0.6 mg/ml was associated with pronounced stimulation of its growth in S. pyogenes , S. aureus , and L. acidophilus .
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-017-3823-x