Study of Endothelial Protective Activity of Phenol-Derived Thrombin and Arginase-2 Inhibitors KUD-259 and KUD-974

We performed correction of endothelial dysfunction with phenol derivatives KUD-259 and KUD-974 containing heteroatomic and heterocyclic structures. Pharmacological activity of KUD-259 and KUD-974 surpassed that of L-norvaline, a non-selective arginase inhibitor.

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2017-08, Vol.163 (4), p.436-438
Main Authors: Pokrovskii, M. V., Korokin, M. V., Kudryavtsev, K. V., Pokrovskaya, T. G., Gudyrev, O. S., Gureev, V. V., Korokina, L. V., Povetkin, S. V.
Format: Article
Language:English
Subjects:
Animals
Arginase - antagonists & inhibitors
Biomedical and Life Sciences
Biomedicine
Cell Biology
Endothelium
Endothelium, Vascular - drug effects
Endothelium, Vascular - metabolism
Internal Medicine
Laboratory Medicine
Male
NG-Nitroarginine Methyl Ester - pharmacology
Nitric oxide
Nitric Oxide - pharmacology
Pathology
Phenol - chemistry
Phenols (Class of compounds)
Rats
Rats, Wistar
Signal Transduction - drug effects
Thrombin
Thrombin - chemistry
Valine - analogs & derivatives
Valine - pharmacology
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Description
Summary:We performed correction of endothelial dysfunction with phenol derivatives KUD-259 and KUD-974 containing heteroatomic and heterocyclic structures. Pharmacological activity of KUD-259 and KUD-974 surpassed that of L-norvaline, a non-selective arginase inhibitor.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-017-3822-y