Chronic urticaria and the metabolic syndrome: a cross‐sectional community‐based study of 11 261 patients

Background Emerging evidence suggests that chronic urticaria (CU) is associated with chronic, low‐grade, inflammatory process. Objective To evaluate the association between CU and metabolic syndrome and its components in a large community‐based medical database. Methods A cross‐sectional study of CU...

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Published in:Journal of the European Academy of Dermatology and Venereology 2018-02, Vol.32 (2), p.276-281
Main Authors: Shalom, G., Magen, E., Babaev, M., Tiosano, S., Vardy, D.A., Linder, D., Horev, A., Saadia, A., Comaneshter, D., Agmon‐Levin, N., Cohen, A.D.
Format: Article
Language:English
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Summary:Background Emerging evidence suggests that chronic urticaria (CU) is associated with chronic, low‐grade, inflammatory process. Objective To evaluate the association between CU and metabolic syndrome and its components in a large community‐based medical database. Methods A cross‐sectional study of CU patients and matched controls was performed. CU was defined as eight urticaria diagnoses (with each two diagnoses registered within a period of 6 weeks) from 2002 to 2012. Data regarding the prevalence of metabolic syndrome, its components and possible complications were collected. Results The study included 11 261 patients with CU and 67 216 controls. In a univariate analysis, CU was significantly associated with higher body mass index (BMI) and a higher prevalence of obesity, diabetes, hyperlipidaemia, hypertension, metabolic syndrome, chronic renal failure and gout. Multivariate analysis demonstrated a significant association between CU and metabolic syndrome (OR = 1.12, 95% CI 1.1–1.2, P < 0.001) and its components – obesity (OR = 1.2, 95% CI 1.1–1.3, P < 0.001), diabetes (OR = 1.08, 95% CI 1.01–1.15, P = 0.001), hyperlipidaemia (OR = 1.2, 95% CI 1.1–1.2, P < 0.001) and hypertension (OR = 1.1, 95% CI 1.1–1.2, P < 0.001). Conclusions CU patients may have one or more undiagnosed components of metabolic syndrome despite their young age. Thus, appropriate targeted screening is advised.
ISSN:0926-9959
1468-3083
DOI:10.1111/jdv.14548