Strain differences in toxic effects of long-lasting isoflurane anaesthesia between Wistar rats and Sprague Dawley rats

We investigated if long-lasting (5 h) anaesthesia with isoflurane has different pharmacological effects in two different rat strains: Wistar and Sprague Dawley. The mean blood pressure was 34% higher in Sprague Dawley rats as compared to the Wistar rats ( p = 0.04). In Wistar rats, the pH value decr...

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Bibliographic Details
Published in:Food and chemical toxicology 2008-11, Vol.46 (11), p.3550-3552
Main Authors: Siller-Matula, J.M., Jilma, B.
Format: Article
Language:English
Subjects:
Alanine Transaminase - metabolism
Anaesthesia
Anesthetics, Inhalation - toxicity
Animals
Aspartate Aminotransferases - metabolism
Biological and medical sciences
Blood Pressure - drug effects
Blood Pressure - physiology
Drug toxicity and drugs side effects treatment
Hydrogen-Ion Concentration
Isoflurane
Isoflurane - toxicity
L-Lactate Dehydrogenase - metabolism
Lactic Acid - blood
Male
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
Rats
Rats, Sprague-Dawley - physiology
Rats, Wistar - physiology
Species Specificity
Sprague Dawley
Strain differences
Wistar
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Summary:We investigated if long-lasting (5 h) anaesthesia with isoflurane has different pharmacological effects in two different rat strains: Wistar and Sprague Dawley. The mean blood pressure was 34% higher in Sprague Dawley rats as compared to the Wistar rats ( p = 0.04). In Wistar rats, the pH value decreased to 7.1, lactate increased by 53%, creatinine increased 2.7-fold, alanine amino transferase and aspartate amino transferase increased more than 4-fold and lactate dehydrogenase increased 9-fold ( p < 0.05). There were no changes in laboratory parameters in Sprague Dawley rats. This indicates that the Wistar rats were more sensitive to a 5 h anaesthesia with isoflurane after a premedication with ketamin/xylazine in the described study design.
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2008.08.033