Cytoplasmic, but not nuclear, p16 expression may signal poor prognosis in high-grade astrocytomas

The negative consequences of the cytoplasmic localization of p16 in patients with high-grade astrocytomas, on their prognosis, was investigated. p16 Expression was examined in 20 anaplastic astrocytoma and 42 glioblastoma patients by immunohistochemical analysis, and the relationship between both cy...

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Bibliographic Details
Published in:Journal of neuro-oncology 2006-05, Vol.77 (3), p.273-277
Main Authors: MUHAMAD THOHAR ARIFIN, HAMA, Seiji, KAJIWARA, Yoshinori, SUGIYAMA, Kazuhiko, SAITO, Taiichi, MATSUURA, Shinya, YAMASAKI, Fumiyuki, ARITA, Kazunori, KURISU, Kaoru
Format: Article
Language:English
Subjects:
Adolescent
Aged
Astrocytoma - metabolism
Astrocytoma - pathology
Astrocytoma - therapy
Biological and medical sciences
Brain Neoplasms - metabolism
Brain Neoplasms - pathology
Brain Neoplasms - therapy
Cell Nucleus - metabolism
Cyclin-Dependent Kinase Inhibitor p16 - genetics
Cyclin-Dependent Kinase Inhibitor p16 - metabolism
Cytoplasm - metabolism
Development. Senescence. Regeneration. Transplantation
Female
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Neoplastic
Glioblastoma - metabolism
Glioblastoma - pathology
Glioblastoma - therapy
Humans
Immunohistochemistry
Injuries of the nervous system and the skull. Diseases due to physical agents
Male
Medical sciences
Middle Aged
Neurology
Prognosis
Survival Analysis
Traumas. Diseases due to physical agents
Tumor Cells, Cultured
Vertebrates: nervous system and sense organs
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Summary:The negative consequences of the cytoplasmic localization of p16 in patients with high-grade astrocytomas, on their prognosis, was investigated. p16 Expression was examined in 20 anaplastic astrocytoma and 42 glioblastoma patients by immunohistochemical analysis, and the relationship between both cytoplasmic and nuclear p16 expression and prognosis analyzed. The cytoplasmic expression of p16 statistically correlated with poor prognosis. On the other hand, no correlation was observed between p16 nuclear expression and patient survival. The cytoplasmic immunoreactivity of p16 appears to be an unfavorable prognostic indicator in high-grade astrocytoma patients. The localization of p16 expression should be determined when evaluating the prognosis of these patients.
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-005-9037-5