Efficacy and safety of misoprostol, dinoprostone and Cook’s balloon for labour induction in women with foetal growth restriction at term

Background and objectives To compare effectiveness and safety of dinoprostone, misoprostol and Cook’s balloon as labour-inducing agents in women with intrauterine growth restriction (IUGR) at term. Methods Retrospective cohort chart review of women diagnosed with foetal growth restriction at term in...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2017-10, Vol.296 (4), p.777-781
Main Authors: Duro-Gómez, Jorge, Garrido-Oyarzún, María Fernanda, Rodríguez-Marín, Ana Belén, de la Torre González, Antonio Jesús, Arjona-Berral, José Eduardo, Castelo-Branco, Camil
Format: Article
Language:English
Subjects:
Administration, Intravaginal
Adult
Delivery, Obstetric
Dinoprostone - administration & dosage
Dinoprostone - adverse effects
Endocrinology
Female
Fetal Growth Retardation - chemically induced
Gynecology
Health risk assessment
Human Genetics
Humans
Labor, Induced - methods
Maternal-Fetal Medicine
Medicine
Medicine & Public Health
Misoprostol - administration & dosage
Misoprostol - adverse effects
Obstetrics/Perinatology/Midwifery
Oxytocics - administration & dosage
Oxytocics - adverse effects
Oxytocin - adverse effects
Pregnancy
Pregnancy Outcome
Retrospective Studies
Spain
Term Birth
Treatment Outcome
Vaginal Creams, Foams, and Jellies - administration & dosage
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Summary:Background and objectives To compare effectiveness and safety of dinoprostone, misoprostol and Cook’s balloon as labour-inducing agents in women with intrauterine growth restriction (IUGR) at term. Methods Retrospective cohort chart review of women diagnosed with foetal growth restriction at term in Reina Sofia Hospital, Cordoba, Spain from January 2014 to December 2015. Registration of baseline characteristics and method of induction was made. The main outcome was time from induction to delivery. Obstetric and perinatal outcomes were also collected. Results A total of 99 women were diagnosed with IUGR in the mentioned period. Of them, 21 women were induced with dinoprostone [dinoprostone group (DG)], 20 with misoprostol (MG) and in 58 with Cook’s balloon (CG). Groups were homogeneous regarding pre-induction Bishop score and parity. The CG required more time (24.36 vs. 19.23 h; p  = 0.02) and more oxytocin dose for conduction of labour from induction to delivery (6.75 vs. 1.24 mUI; p  
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-017-4492-8