Association of CnB 5I/5D promoter gene polymorphism and serum calcineurin levels in early onset of coronary artery disease of south Indian cohort

Calcineurin, a serine/threonine phosphatase is a calcium dependent protein which on activation triggers transcriptional up regulation of inflammatory genes associated with inflammation in the arteries and progressive formation of plaques in CAD. The present investigation is aimed to study the possib...

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Bibliographic Details
Published in:Gene 2017-10, Vol.632, p.1-6
Main Authors: Maddhuri, Sailaja, Bandaru, Srinivas, Bhukya, Chaitanya, Cingeetham, Vinod, Malempati, Amaresh Rao, Deepika, M.L.N., Nallari, Pratibha, Mundluru, Hema Prasad
Format: Article
Language:English
Subjects:
Adult
Atherosclerosis
Calcineurin
Calcineurin - blood
Calcineurin - genetics
Case-Control Studies
Coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - genetics
Female
Humans
INDEL Mutation
India
Male
Polymorphism, Genetic
PPP3R1
Promoter Regions, Genetic
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Summary:Calcineurin, a serine/threonine phosphatase is a calcium dependent protein which on activation triggers transcriptional up regulation of inflammatory genes associated with inflammation in the arteries and progressive formation of plaques in CAD. The present investigation is aimed to study the possible association of Calcineurin encoding gene PPP3R1 (CnB 5I/5D) polymorphism in correlation with serum levels of calcineurin in coronary artery disease (CAD). A total of 300 angiographically documented CAD patients and 300 age, gender ethnicity matched healthy controls were recruited for the study. Serum Calcineurin levels were estimated by enzyme-linked immunosorbent assay (ELISA) and genotypes were determined based on PCR-RFLP. The CnB 5I/5D variation was found to be significantly associated with CAD (p
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2017.08.002