Swim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertension

Investigate to what extent low-intensity swim training for six weeks counterbalances the adverse remodeling due to the advance of pathological hypertrophy in the left ventricle (LV) structural and mechanical properties in the early compensated phase of hypertension in male SHR. Four-month-old male S...

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Bibliographic Details
Published in:Life sciences (1973) 2017-10, Vol.187, p.42-49
Main Authors: Locatelli, Jamille, Paiva, Nívia C.N., Carvalho, Sara H.R., Lavorato, Victor N., Gomes, Luis Henrique L.S., Castro, Quênia J.T., Grabe-Guimarães, Andrea, Carneiro, Cláudia M., Natali, Antônio J., Isoldi, Mauro C.
Format: Article
Language:English
Subjects:
Animals
Blood pressure
Blood Pressure - physiology
Cardiac remodeling
Cardiomyocytes
Collagen (type III)
Collagen Type I - metabolism
Collagen Type III - metabolism
Counterbalances
Electric Stimulation
Heart Rate - physiology
Heart Ventricles - metabolism
Heart Ventricles - pathology
Hypertension
Hypertension - metabolism
Hypertension - pathology
Hypertension - physiopathology
Hypertension - therapy
Hypertrophy
Inflammation
Male
Males
Mechanical properties
Muscle Contraction - physiology
Muscle Relaxation - physiology
Myocytes
Myocytes, Cardiac - pathology
Myocytes, Cardiac - physiology
Pathology
Physical Conditioning, Animal
Physical Therapy Modalities
Rats
Rodents
Spontaneously hypertensive rats
Studies
Swim training
Swimming
Training
Ventricle
Ventricular Remodeling - physiology
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Summary:Investigate to what extent low-intensity swim training for six weeks counterbalances the adverse remodeling due to the advance of pathological hypertrophy in the left ventricle (LV) structural and mechanical properties in the early compensated phase of hypertension in male SHR. Four-month-old male SHR and Wistar rats were randomly divided into Sed (sedentary) and Ex (exercised) groups. The exercised rats were submitted to a swimming protocol (1h/day, 5times/week, no additional load) for six weeks. LV tissue and isolated myocytes were used to assess structural and mechanical properties. Myocytes were stimulted at frequencies (F) of 1 and 3Hz at 37°C. Exercised SHR showed improvement in cardiovascular parameters compared to sedentary SHR (mean arterial pressure: 13.22%; resting HR: 14.28.%). About structural and mechanical properties, swim training induced a decrease in LV myocyte thickness (10.85%), number of inflammatory cells (21.24%); collagen type III (74.23%) and type I (85.6%) fiber areas; amplitude of single myocyte shortening (47% to F1 and 28.46% to F3), timecourses of shortening (16.5% to F1 and 7.55% to F3) and relaxation (15.31% to F3) compared to sedentary SHR. Six weeks of swim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertension in male SHR.
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2017.08.014