Tracking STAT nuclear traffic

Accurate cellular localization is crucial for the effective function of most signalling molecules and nuclear translocation is central to the function of transcription factors. The passage of large molecules between the cytoplasm and nucleus is restricted, and this restriction affords a mechanism to...

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Bibliographic Details
Published in:Nature Reviews: Immunology 2006-08, Vol.6 (8), p.602-612
Main Authors: Reich, Nancy C, Liu, Ling
Format: Article
Language:English
Subjects:
Active Transport, Cell Nucleus
Animals
Cell Nucleus - metabolism
Chemokines
Cytokines
DNA - metabolism
Growth factors
Humans
Interferon-Stimulated Gene Factor 3, gamma Subunit - metabolism
Kinases
Ligands
Localization
Phosphorylation
Proteins
STAT Transcription Factors - metabolism
STAT3 Transcription Factor - metabolism
STAT5 Transcription Factor - metabolism
Transcription factors
Viral infections
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Summary:Accurate cellular localization is crucial for the effective function of most signalling molecules and nuclear translocation is central to the function of transcription factors. The passage of large molecules between the cytoplasm and nucleus is restricted, and this restriction affords a mechanism to regulate transcription by controlling the access of transcription factors to the nucleus. In this Review, we focus on the signal transducer and activator of transcription (STAT) family of transcription factors. The regulation of the nuclear trafficking of STAT-family members is diverse. Some STAT proteins constitutively shuttle between the nucleus and cytoplasm, whereas others require tyrosine phosphorylation for nuclear localization. In either case, the regulation of nuclear trafficking can provide a target for therapeutic intervention.
ISSN:1474-1733
1474-1741
1365-2567
DOI:10.1038/nri1885