Low adherence to antidepressants is associated with increased mortality in Parkinson disease patients

The purpose of this study was to evaluate the relationship between adherence to antidepressants (AD) and all-cause mortality in a population-based cohort of patients with Parkinson's Disease (PD). From a database of more than 4 million people, 8553 patients with PD who purchased an AD at least...

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Bibliographic Details
Published in:Parkinsonism & related disorders 2017-10, Vol.43, p.92-96
Main Authors: Shoval, Gal, Stubbs, Brendon, Balicer, Ran D., Feldman, Becca, Hoshen, Moshe, Zalsman, Gil, Sagy, Roi, Hochman, Eldar, Weizman, Abraham, Krivoy, Amir
Format: Article
Language:English
Subjects:
Adherence
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Antidepressants
Antidepressive Agents - therapeutic use
Anxiety
Cohort Studies
Depression
Depressive Disorder - drug therapy
Depressive Disorder - epidemiology
Female
Humans
Male
Middle Aged
Mortality
Outcome Assessment (Health Care)
Parkinson disease
Parkinson Disease - epidemiology
Parkinson Disease - mortality
Patient Compliance - psychology
Proportional Hazards Models
Young Adult
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Summary:The purpose of this study was to evaluate the relationship between adherence to antidepressants (AD) and all-cause mortality in a population-based cohort of patients with Parkinson's Disease (PD). From a database of more than 4 million people, 8553 patients with PD who purchased an AD at least once between the years 2008–2011 were retrospectively followed for all-cause mortality over 4-years. Adherence was measured as a ratio between dispensed and prescribed durations and was modeled as: non-adherence (80%, n = 4219) adherence. Multivariable survival analyses adjusted for demographic and clinical variables including physical comorbidities known to influence mortality were conducted, however there was no adjustment for other psychiatric disorders and medications. Unadjusted mortality rates were 20.4%, 25.1%, 23.4% and 25.6% in those classified as non-adherent, poor, moderate and good adherence respectively (χ2 = 18.45, p 
ISSN:1353-8020
1873-5126
DOI:10.1016/j.parkreldis.2017.07.032