A systematic literature review of neuroimaging research on developmental stuttering between 1995 and 2016

Stuttering is a disorder that affects millions of people all over the world. Over the past two decades, there has been a great deal of interest in investigating the neural basis of the disorder. This systematic literature review is intended to provide a comprehensive summary of the neuroimaging lite...

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Bibliographic Details
Published in:Journal of fluency disorders 2018-03, Vol.55, p.6-45
Main Authors: Etchell, Andrew C., Civier, Oren, Ballard, Kirrie J., Sowman, Paul F.
Format: Article
Language:English
Subjects:
Brain
Children
diffusion MRI
DTI
EEG
fMRI
Literature reviews
Magnetic resonance imaging
Magnetoencephalography
Medical imaging
MEG
morphology
Neuroimaging
Neurology
PET
review
Sex differences
Stuttering
TMS
tractography
Transcranial magnetic stimulation
VBM
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Summary:Stuttering is a disorder that affects millions of people all over the world. Over the past two decades, there has been a great deal of interest in investigating the neural basis of the disorder. This systematic literature review is intended to provide a comprehensive summary of the neuroimaging literature on developmental stuttering. It is a resource for researchers to quickly and easily identify relevant studies for their areas of interest and enable them to determine the most appropriate methodology to utilize in their work. The review also highlights gaps in the literature in terms of methodology and areas of research. We conducted a systematic literature review on neuroimaging studies on developmental stuttering according to the PRISMA guidelines. We searched for articles in the pubmed database containing “stuttering” OR “stammering” AND either “MRI”, “PET”, “EEG”, “MEG”, “TMS”or “brain” that were published between 1995/​01/​01 and 2016/​01/​01. The search returned a total of 359 items with an additional 26 identified from a manual search. Of these, there were a total of 111 full text articles that met criteria for inclusion in the systematic literature review. We also discuss neuroimaging studies on developmental stuttering published throughout 2016. The discussion of the results is organized first by methodology and second by population (i.e., adults or children) and includes tables that contain all items returned by the search. There are widespread abnormalities in the structural architecture and functional organization of the brains of adults and children who stutter. These are evident not only in speech tasks, but also non-speech tasks. Future research should make greater use of functional neuroimaging and noninvasive brain stimulation, and employ structural methodologies that have greater sensitivity. Newly planned studies should also investigate sex differences, focus on augmenting treatment, examine moments of dysfluency and longitudinally or cross-sectionally investigate developmental trajectories in stuttering.
ISSN:0094-730X
1873-801X
DOI:10.1016/j.jfludis.2017.03.007