Chirality Sensing of α‑Hydroxyphosphonates by N-tert-Butyl Sulfinyl Squaramide

N-tert-Butyl sulfinyl squaramides were used for chiral discrimination of α-hydroxy­phosphonates using 31P NMR. A free energy relationship study indicates that both steric and the electronic effects influence the chiral recognition of the donors.

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Bibliographic Details
Published in:Organic letters 2017-08, Vol.19 (16), p.4191-4194
Main Authors: Li, Yao, Yang, Guo-Hui, He, Cyndi Qixin, Li, Xin, Houk, K. N, Cheng, Jin-Pei
Format: Article
Language:English
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Summary:N-tert-Butyl sulfinyl squaramides were used for chiral discrimination of α-hydroxy­phosphonates using 31P NMR. A free energy relationship study indicates that both steric and the electronic effects influence the chiral recognition of the donors.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b01743