Fusidic acid resistance in community isolates of methicillin susceptible Staphylococcus aureus and the use of topical fusidic acid: a retrospective case–control study

Resistance to fusidic acid among community methicillin susceptible Staphylococcus aureus (MSSA) isolates in the United Kingdom and prescriptions for fusidic acid have both doubled over the past 6 years. A retrospective case–control study was undertaken to test the hypothesis that the use of topical...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2004-03, Vol.23 (3), p.299-302
Main Authors: Mason, Brendan W, Howard, Anthony J
Format: Article
Language:English
Subjects:
Administration, Topical
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - adverse effects
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimicrobial resistance
Biological and medical sciences
Case-Control Studies
Case–control study
Drug Resistance, Bacterial
Fusidic acid
Fusidic Acid - administration & dosage
Fusidic Acid - adverse effects
Humans
Medical sciences
Methicillin - pharmacology
Methicillin susceptible Staphylococcus aureus
Pharmacology. Drug treatments
Retrospective Studies
Staphylococcal Infections - drug therapy
Staphylococcal Infections - microbiology
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus aureus - isolation & purification
Surveys and Questionnaires
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Summary:Resistance to fusidic acid among community methicillin susceptible Staphylococcus aureus (MSSA) isolates in the United Kingdom and prescriptions for fusidic acid have both doubled over the past 6 years. A retrospective case–control study was undertaken to test the hypothesis that the use of topical fusidic acid is associated with the isolation of resistant organisms. A statistically significant association was found between fusidic acid resistance in MSSA isolates and exposure to topical fusidic acid (odds ratio: 2.77, 95%CI 1.01–7.93, P=0.027). This study demonstrates for the first time an association between the use of topical fusidic acid and resistance at the individual patient level and supports the hypothesis that the observed increase in resistance is causally associated with the increased use of topical fusidic acid.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2003.09.013