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The Effect of Nonnutritive Sweeteners Added to a Liquid Diet on Volume and Caloric Intake and Weight Gain in Rats
Objective Long‐term effects of diet beverage consumption on the regulation of caloric intake is unclear. The goal of this study was to investigate whether the chronic intake of a liquid diet with nonnutritive sweeteners (NNS) would lead to greater appetite and weight gain. Methods Wistar rats were f...
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| Published in: | Obesity (Silver Spring, Md.) Md.), 2017-09, Vol.25 (9), p.1556-1563 |
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| Main Authors: | , , , |
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| Language: | English |
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| container_end_page | 1563 |
| container_issue | 9 |
| container_start_page | 1556 |
| container_title | Obesity (Silver Spring, Md.) |
| container_volume | 25 |
| creator | Bissonnette, David J. List, Samantha Knoblich, Penny Hadley, M. |
| description | Objective
Long‐term effects of diet beverage consumption on the regulation of caloric intake is unclear. The goal of this study was to investigate whether the chronic intake of a liquid diet with nonnutritive sweeteners (NNS) would lead to greater appetite and weight gain.
Methods
Wistar rats were fed a liquid diet (Osmolite) sweetened with nutritive sweetener (NS; sucrose) and NNS (stevia and saccharin) or a nonsweetened control. Intakes and weight gain were measured. Phases 1 and 2 investigated sweetness preference, phase 3 used diets with or without sweeteners, and phase 4 measured the effect on volume of food and caloric intake of alternating between NNS, NS, and control diets.
Results
In phase 1, rats preferred: stevia, 0.10%; saccharin, 0.20%; and sucrose, 15%. In phase 2, rats preferred the sweetened diet over the control. In phase 3, rats fed the NS diet consumed less volume and more calories but gained less weight. In phase 4, when altering diet from NNS to NS, no differences were observed in appetite or weight gain.
Conclusions
Using sucrose‐sweetened diet as a control, increased weight gain with the ingestion of NNS was observed. However, using a nonsweetened control, neither increased caloric intake nor weight gain occurred with NNS intake. Alternating diets between NNS, NS, and control did not affect the appetite. |
| doi_str_mv | 10.1002/oby.21920 |
| format | article |
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Long‐term effects of diet beverage consumption on the regulation of caloric intake is unclear. The goal of this study was to investigate whether the chronic intake of a liquid diet with nonnutritive sweeteners (NNS) would lead to greater appetite and weight gain.
Methods
Wistar rats were fed a liquid diet (Osmolite) sweetened with nutritive sweetener (NS; sucrose) and NNS (stevia and saccharin) or a nonsweetened control. Intakes and weight gain were measured. Phases 1 and 2 investigated sweetness preference, phase 3 used diets with or without sweeteners, and phase 4 measured the effect on volume of food and caloric intake of alternating between NNS, NS, and control diets.
Results
In phase 1, rats preferred: stevia, 0.10%; saccharin, 0.20%; and sucrose, 15%. In phase 2, rats preferred the sweetened diet over the control. In phase 3, rats fed the NS diet consumed less volume and more calories but gained less weight. In phase 4, when altering diet from NNS to NS, no differences were observed in appetite or weight gain.
Conclusions
Using sucrose‐sweetened diet as a control, increased weight gain with the ingestion of NNS was observed. However, using a nonsweetened control, neither increased caloric intake nor weight gain occurred with NNS intake. Alternating diets between NNS, NS, and control did not affect the appetite.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.21920</identifier><identifier>PMID: 28763168</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Animals ; Appetite ; Artificial sweeteners ; Beverages ; Body Weight - physiology ; Diet ; Energy Intake - physiology ; Food ; Gene expression ; Male ; Metabolism ; Neurosciences ; Non-Nutritive Sweeteners - adverse effects ; Non-Nutritive Sweeteners - pharmacology ; Nutrition research ; Obesity ; Preferences ; Proteins ; Rats ; Rats, Wistar ; Rodents ; Studies ; Sucrose ; Weight control ; Weight Gain - drug effects</subject><ispartof>Obesity (Silver Spring, Md.), 2017-09, Vol.25 (9), p.1556-1563</ispartof><rights>2017 The Obesity Society</rights><rights>2017 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Sep 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3880-62dd1568f841d77f1eefbd317533dbc5f908b4e554a024303ecd0584ce6edb253</citedby><cites>FETCH-LOGICAL-c3880-62dd1568f841d77f1eefbd317533dbc5f908b4e554a024303ecd0584ce6edb253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.21920$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.21920$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28763168$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bissonnette, David J.</creatorcontrib><creatorcontrib>List, Samantha</creatorcontrib><creatorcontrib>Knoblich, Penny</creatorcontrib><creatorcontrib>Hadley, M.</creatorcontrib><title>The Effect of Nonnutritive Sweeteners Added to a Liquid Diet on Volume and Caloric Intake and Weight Gain in Rats</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
Long‐term effects of diet beverage consumption on the regulation of caloric intake is unclear. The goal of this study was to investigate whether the chronic intake of a liquid diet with nonnutritive sweeteners (NNS) would lead to greater appetite and weight gain.
Methods
Wistar rats were fed a liquid diet (Osmolite) sweetened with nutritive sweetener (NS; sucrose) and NNS (stevia and saccharin) or a nonsweetened control. Intakes and weight gain were measured. Phases 1 and 2 investigated sweetness preference, phase 3 used diets with or without sweeteners, and phase 4 measured the effect on volume of food and caloric intake of alternating between NNS, NS, and control diets.
Results
In phase 1, rats preferred: stevia, 0.10%; saccharin, 0.20%; and sucrose, 15%. In phase 2, rats preferred the sweetened diet over the control. In phase 3, rats fed the NS diet consumed less volume and more calories but gained less weight. In phase 4, when altering diet from NNS to NS, no differences were observed in appetite or weight gain.
Conclusions
Using sucrose‐sweetened diet as a control, increased weight gain with the ingestion of NNS was observed. However, using a nonsweetened control, neither increased caloric intake nor weight gain occurred with NNS intake. Alternating diets between NNS, NS, and control did not affect the appetite.</description><subject>Animals</subject><subject>Appetite</subject><subject>Artificial sweeteners</subject><subject>Beverages</subject><subject>Body Weight - physiology</subject><subject>Diet</subject><subject>Energy Intake - physiology</subject><subject>Food</subject><subject>Gene expression</subject><subject>Male</subject><subject>Metabolism</subject><subject>Neurosciences</subject><subject>Non-Nutritive Sweeteners - adverse effects</subject><subject>Non-Nutritive Sweeteners - pharmacology</subject><subject>Nutrition research</subject><subject>Obesity</subject><subject>Preferences</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Studies</subject><subject>Sucrose</subject><subject>Weight control</subject><subject>Weight Gain - drug effects</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kUFP3DAQhS3UCij00D-ALPXSHhbGcZw4R7qlgLQCidJCT5ETj8E0a7O2U7T_voZQDpWQRprR6Jun0XuEfGCwzwCKA9-t9wvWFLBBtlnDYVbz5vrNyyzZFnkX4x1AWYFgm2SrkHXFWSW3yeryFumRMdgn6g09886NKdhk_yD9_oCY0GGI9FBr1DR5qujCrkar6VeL-cLRn34Yl0iV03SuBh9sT09dUr-n1RXam9tEj5V1NNeFSnGXvDVqiPj-ue-QH9-OLucns8X58en8cDHruZQwqwqtmaikkSXTdW0Youk0Z7XgXHe9MA3IrkQhSgVFyYFjr0HIsscKdVcIvkM-Tbr3wa9GjKld2tjjMCiHfoxt9ks8-gBNRj_-h975Mbj8Xaa4qDlUwDL1eaL64GMMaNr7YJcqrFsG7WMObc6hfcohs3vPimO3RP1C_jM-AwcT8GAHXL-u1J5_-TVJ_gVokZA-</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Bissonnette, David J.</creator><creator>List, Samantha</creator><creator>Knoblich, Penny</creator><creator>Hadley, M.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201709</creationdate><title>The Effect of Nonnutritive Sweeteners Added to a Liquid Diet on Volume and Caloric Intake and Weight Gain in Rats</title><author>Bissonnette, David J. ; List, Samantha ; Knoblich, Penny ; Hadley, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3880-62dd1568f841d77f1eefbd317533dbc5f908b4e554a024303ecd0584ce6edb253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Appetite</topic><topic>Artificial sweeteners</topic><topic>Beverages</topic><topic>Body Weight - physiology</topic><topic>Diet</topic><topic>Energy Intake - physiology</topic><topic>Food</topic><topic>Gene expression</topic><topic>Male</topic><topic>Metabolism</topic><topic>Neurosciences</topic><topic>Non-Nutritive Sweeteners - adverse effects</topic><topic>Non-Nutritive Sweeteners - pharmacology</topic><topic>Nutrition research</topic><topic>Obesity</topic><topic>Preferences</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Studies</topic><topic>Sucrose</topic><topic>Weight control</topic><topic>Weight Gain - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bissonnette, David J.</creatorcontrib><creatorcontrib>List, Samantha</creatorcontrib><creatorcontrib>Knoblich, Penny</creatorcontrib><creatorcontrib>Hadley, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Complete (ProQuest Database)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database (Proquest)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bissonnette, David J.</au><au>List, Samantha</au><au>Knoblich, Penny</au><au>Hadley, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Nonnutritive Sweeteners Added to a Liquid Diet on Volume and Caloric Intake and Weight Gain in Rats</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2017-09</date><risdate>2017</risdate><volume>25</volume><issue>9</issue><spage>1556</spage><epage>1563</epage><pages>1556-1563</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><notes>The authors declared no conflict of interest.</notes><notes>Disclosure</notes><notes>Supported by Minnesota State University, Mankato, Douglas R. Moore Faculty Lectureship, and the Departments of Biology, Chemistry and Geology, and Family Consumer Science.</notes><notes>Funding agencies</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Objective
Long‐term effects of diet beverage consumption on the regulation of caloric intake is unclear. The goal of this study was to investigate whether the chronic intake of a liquid diet with nonnutritive sweeteners (NNS) would lead to greater appetite and weight gain.
Methods
Wistar rats were fed a liquid diet (Osmolite) sweetened with nutritive sweetener (NS; sucrose) and NNS (stevia and saccharin) or a nonsweetened control. Intakes and weight gain were measured. Phases 1 and 2 investigated sweetness preference, phase 3 used diets with or without sweeteners, and phase 4 measured the effect on volume of food and caloric intake of alternating between NNS, NS, and control diets.
Results
In phase 1, rats preferred: stevia, 0.10%; saccharin, 0.20%; and sucrose, 15%. In phase 2, rats preferred the sweetened diet over the control. In phase 3, rats fed the NS diet consumed less volume and more calories but gained less weight. In phase 4, when altering diet from NNS to NS, no differences were observed in appetite or weight gain.
Conclusions
Using sucrose‐sweetened diet as a control, increased weight gain with the ingestion of NNS was observed. However, using a nonsweetened control, neither increased caloric intake nor weight gain occurred with NNS intake. Alternating diets between NNS, NS, and control did not affect the appetite.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>28763168</pmid><doi>10.1002/oby.21920</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1930-7381 |
| ispartof | Obesity (Silver Spring, Md.), 2017-09, Vol.25 (9), p.1556-1563 |
| issn | 1930-7381 1930-739X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1925287609 |
| source | Wiley |
| subjects | Animals Appetite Artificial sweeteners Beverages Body Weight - physiology Diet Energy Intake - physiology Food Gene expression Male Metabolism Neurosciences Non-Nutritive Sweeteners - adverse effects Non-Nutritive Sweeteners - pharmacology Nutrition research Obesity Preferences Proteins Rats Rats, Wistar Rodents Studies Sucrose Weight control Weight Gain - drug effects |
| title | The Effect of Nonnutritive Sweeteners Added to a Liquid Diet on Volume and Caloric Intake and Weight Gain in Rats |
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