The Effect of Nonnutritive Sweeteners Added to a Liquid Diet on Volume and Caloric Intake and Weight Gain in Rats

Objective Long‐term effects of diet beverage consumption on the regulation of caloric intake is unclear. The goal of this study was to investigate whether the chronic intake of a liquid diet with nonnutritive sweeteners (NNS) would lead to greater appetite and weight gain. Methods Wistar rats were f...

Full description

Saved in:
Bibliographic Details
Published in:Obesity (Silver Spring, Md.) Md.), 2017-09, Vol.25 (9), p.1556-1563
Main Authors: Bissonnette, David J., List, Samantha, Knoblich, Penny, Hadley, M.
Format: Article
Language:English
Subjects:
Animals
Appetite
Artificial sweeteners
Beverages
Body Weight - physiology
Diet
Energy Intake - physiology
Food
Gene expression
Male
Metabolism
Neurosciences
Non-Nutritive Sweeteners - adverse effects
Non-Nutritive Sweeteners - pharmacology
Nutrition research
Obesity
Preferences
Proteins
Rats
Rats, Wistar
Rodents
Studies
Sucrose
Weight control
Weight Gain - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective Long‐term effects of diet beverage consumption on the regulation of caloric intake is unclear. The goal of this study was to investigate whether the chronic intake of a liquid diet with nonnutritive sweeteners (NNS) would lead to greater appetite and weight gain. Methods Wistar rats were fed a liquid diet (Osmolite) sweetened with nutritive sweetener (NS; sucrose) and NNS (stevia and saccharin) or a nonsweetened control. Intakes and weight gain were measured. Phases 1 and 2 investigated sweetness preference, phase 3 used diets with or without sweeteners, and phase 4 measured the effect on volume of food and caloric intake of alternating between NNS, NS, and control diets. Results In phase 1, rats preferred: stevia, 0.10%; saccharin, 0.20%; and sucrose, 15%. In phase 2, rats preferred the sweetened diet over the control. In phase 3, rats fed the NS diet consumed less volume and more calories but gained less weight. In phase 4, when altering diet from NNS to NS, no differences were observed in appetite or weight gain. Conclusions Using sucrose‐sweetened diet as a control, increased weight gain with the ingestion of NNS was observed. However, using a nonsweetened control, neither increased caloric intake nor weight gain occurred with NNS intake. Alternating diets between NNS, NS, and control did not affect the appetite.
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.21920