Structural and functional assessment after intravitreal injection of ranibizumab in diabetic macular edema

Purpose To evaluate structure and function improvement in central retina by optical coherence tomography (OCT) and multifocal electroretinography (mf-ERG) in diabetic macular edema (DME) patients after intravitreal injection of ranibizumab (IVR) treatment. Methods Twenty-seven eyes in 27 patients wi...

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Bibliographic Details
Published in:Documenta ophthalmologica 2017-12, Vol.135 (3), p.165-173
Main Authors: Fu, YuDong, Wang, Ping, Meng, XuXia, Du, Zhaodong, Wang, DaBo
Format: Article
Language:English
Subjects:
Acuity
Aged
Angiogenesis Inhibitors - administration & dosage
Diabetes
Diabetes mellitus
Diabetic Retinopathy - drug therapy
Diabetic Retinopathy - physiopathology
Edema
Electroretinograms
Electroretinography
Female
Humans
Immunotherapy
Injection
Intravitreal Injections
Macula Lutea - pathology
Macula Lutea - physiopathology
Macular Edema - drug therapy
Macular Edema - physiopathology
Male
Medicine
Medicine & Public Health
Middle Aged
Monoclonal antibodies
Ophthalmology
Original Research Article
Ranibizumab - administration & dosage
Retina
Retina - pathology
Retina - physiopathology
Structure-function relationships
Tomography, Optical Coherence
Treatment Outcome
Visual Acuity
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Summary:Purpose To evaluate structure and function improvement in central retina by optical coherence tomography (OCT) and multifocal electroretinography (mf-ERG) in diabetic macular edema (DME) patients after intravitreal injection of ranibizumab (IVR) treatment. Methods Twenty-seven eyes in 27 patients with DME received three consecutive monthly injections of IVR (0.05 ml, 10 mg/ml) and as needed thereafter. The clinical parameters of best-corrected visual acuity (BCVA), central foveal thickness (CFT) and mf-ERG were monitored for 6 months before and after IVR. The findings at baseline, 1, 3 and 6 months were analyzed. Correlation and regression analyses were performed on BCVA, CFT, mf-ERG amplitude and implicit time of the N1 and P1 waves. Results IVR significantly improved visual acuity from the beginning of the treatment ( P  
ISSN:0012-4486
1573-2622
DOI:10.1007/s10633-017-9604-z