BDNF Val66Met but not transcranial direct current stimulation affects motor learning after stroke

tDCS is a non-invasive neuromodulation technique that has been reported to improve motor skill learning after stroke. However, the contribution of tDCS to motor skill learning has only been investigated in a small number of studies. In addition, it is unclear if tDCS effects are mediated by activity...

Full description

Saved in:
Bibliographic Details
Published in:Brain stimulation 2017-09, Vol.10 (5), p.882-892
Main Authors: van der Vliet, Rick, Ribbers, Gerard M., Vandermeeren, Yves, Frens, Maarten A., Selles, Ruud W.
Format: Article
Language:English
Subjects:
Aged
BDNF Val66Met
Brain-Derived Neurotrophic Factor - genetics
Double-Blind Method
Female
Humans
Learning - physiology
Male
Methionine - genetics
Middle Aged
Motor Cortex - physiology
Motor skill learning
Motor Skills - physiology
Neuromodulation
Stroke - genetics
Stroke - physiopathology
Stroke - therapy
Stroke rehabilitation
tDCS
Transcranial Direct Current Stimulation - methods
Treatment Outcome
Valine - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:tDCS is a non-invasive neuromodulation technique that has been reported to improve motor skill learning after stroke. However, the contribution of tDCS to motor skill learning has only been investigated in a small number of studies. In addition, it is unclear if tDCS effects are mediated by activity-dependent BDNF release and dependent on timing of tDCS relative to training. Investigate the role of activity-dependent BDNF release and timing of tDCS relative to training in motor skill learning. Double-blind, between-subjects randomized controlled trial of circuit tracing task improvement (ΔMotor skill) in 80 chronic stroke patients who underwent tDCS and were genotyped for BDNF Val66Met. Patients received either short-lasting tDCS (20 min) during training (short-lasting online group), long-lasting tDCS (10 min–25 min break – 10 min) one day before training (long-lasting offline group), short-lasting tDCS one day before training (short-lasting offline group), or sham tDCS. ΔMotor skill was defined as the skill difference on the circuit tracing task between day one and day nine of the study. Having at least one BDNF Met allele was found to diminish ΔMotor skill (βBDNF,Met = −0.217 95%HDI = [−0.431 –0.0116]), indicating activity-dependent BDNF release is important for motor skill learning after stroke. However, none of the tDCS protocols affected ΔMotor skill (βShort-lasting,online = 0.0908 95%HDI = [-0.227 0.403]; βLong-lasting,offline = 0.0242 95%HDI = [-0.292 0.349]; βShort-lasting,offline = −0.108 95%HDI = [-0.433 0.210]). BDNF Val66Met is a determinant of motor skill learning after stroke and could be important for prognostic models. tDCS does not modulate motor skill learning in our study and might be less effective than previously assumed. •Chronic stroke patients who carry a BDNF Val66Met allele acquire a motor skill more slowly, as is true for healthy carriers.•Screening for BDNF Val66Met after stroke might improve models of stroke recovery.•tDCS does not modulate motor skill learning in our study and might be less effective than previously assumed.•Neuromodulation with tDCS might only be effective in a highly selected group of stroke patients.
ISSN:1935-861X
1876-4754
DOI:10.1016/j.brs.2017.07.004