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Effects of BPF on steroid hormone homeostasis and gene expression in the hypothalamic–pituitary–gonadal axis of zebrafish
Bisphenol F (BPF) has been frequently detected in various environmental compartments, and previous studies found that BPF exhibits similar estrogenic and anti-androgenic effects on the mammalian endocrine system to those of bisphenol A (BPA). However, the potential disrupting effects of BPF on aquat...
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| Published in: | Environmental science and pollution research international 2017-09, Vol.24 (26), p.21311-21322 |
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| creator | Yang, Qian Yang, Xianhai Liu, Jining Ren, Wenjuan Chen, Yingwen Shen, Shubao |
| description | Bisphenol F (BPF) has been frequently detected in various environmental compartments, and previous studies found that BPF exhibits similar estrogenic and anti-androgenic effects on the mammalian endocrine system to those of bisphenol A (BPA). However, the potential disrupting effects of BPF on aquatic organisms and the underling disrupting mechanisms have not been investigated. In this study, the potential disrupting mechanisms of BPF on the hypothalamic–pituitary–gonadal (HPG) axis and liver were probed by employing the OECD 21-day short-term fecundity assay in zebrafish. The results show that BPF exposure (1 mg/L) impaired the reproductive function of zebrafish, as exemplified by alterations to testicular and ovarian histology of the treated zebrafish. Homogenate testosterone (T) levels in male zebrafish decreased in a concentration-dependent manner, and 17β-estradiol (E2) levels increased significantly when fish were exposed to 0.1 and 1 mg/L BPF. The real-time polymerase chain reaction was performed to examine gene expression in the HPG axis and liver. Hepatic vitellogenin expression was significantly upregulated in males, suggesting that BPF possesses estrogenic activity. The disturbed hormone balance was enhanced by the significant changes in gene expression along the HPG axis. These alterations suggest that BPF leads to adverse effects on the endocrine system of teleost fish, and that these effects were more prominent in males than in females. |
| doi_str_mv | 10.1007/s11356-017-9773-z |
| format | article |
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However, the potential disrupting effects of BPF on aquatic organisms and the underling disrupting mechanisms have not been investigated. In this study, the potential disrupting mechanisms of BPF on the hypothalamic–pituitary–gonadal (HPG) axis and liver were probed by employing the OECD 21-day short-term fecundity assay in zebrafish. The results show that BPF exposure (1 mg/L) impaired the reproductive function of zebrafish, as exemplified by alterations to testicular and ovarian histology of the treated zebrafish. Homogenate testosterone (T) levels in male zebrafish decreased in a concentration-dependent manner, and 17β-estradiol (E2) levels increased significantly when fish were exposed to 0.1 and 1 mg/L BPF. The real-time polymerase chain reaction was performed to examine gene expression in the HPG axis and liver. Hepatic vitellogenin expression was significantly upregulated in males, suggesting that BPF possesses estrogenic activity. The disturbed hormone balance was enhanced by the significant changes in gene expression along the HPG axis. These alterations suggest that BPF leads to adverse effects on the endocrine system of teleost fish, and that these effects were more prominent in males than in females.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-017-9773-z</identifier><identifier>PMID: 28741210</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>17β-Estradiol ; Animals ; Aquatic organisms ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Benzhydryl Compounds - toxicity ; Bisphenol A ; Compartments ; Danio rerio ; Earth and Environmental Science ; Ecotoxicology ; Endocrine Disruptors - toxicity ; Endocrine system ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental science ; Estrogenic activity ; Fecundity ; Female ; Fish ; Gene expression ; Gene Expression - drug effects ; Gonadal Steroid Hormones - genetics ; Gonadal Steroid Hormones - metabolism ; Gonads - drug effects ; Gonads - metabolism ; Histology ; Homeostasis ; Homeostasis - drug effects ; Hypothalamo-Hypophyseal System - drug effects ; Hypothalamo-Hypophyseal System - metabolism ; Hypothalamus ; Liver ; Male ; Males ; Phenols - toxicity ; Pituitary ; Polymerase chain reaction ; Research Article ; Sex differences ; Sex hormones ; Testosterone ; Vitellogenin ; Waste Water Technology ; Water Management ; Water Pollutants, Chemical - toxicity ; Water Pollution Control ; Xenoestrogens ; Zebrafish ; Zebrafish - genetics ; Zebrafish - metabolism</subject><ispartof>Environmental science and pollution research international, 2017-09, Vol.24 (26), p.21311-21322</ispartof><rights>Springer-Verlag GmbH Germany 2017</rights><rights>Environmental Science and Pollution Research is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-631af6350de6ffccbc0967e43b7c4712ff49cf0b8657e25b3e92dc179719df4c3</citedby><cites>FETCH-LOGICAL-c475t-631af6350de6ffccbc0967e43b7c4712ff49cf0b8657e25b3e92dc179719df4c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1956534875/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1956534875?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,783,787,11700,27936,27937,36072,36073,44375,75223</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28741210$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Qian</creatorcontrib><creatorcontrib>Yang, Xianhai</creatorcontrib><creatorcontrib>Liu, Jining</creatorcontrib><creatorcontrib>Ren, Wenjuan</creatorcontrib><creatorcontrib>Chen, Yingwen</creatorcontrib><creatorcontrib>Shen, Shubao</creatorcontrib><title>Effects of BPF on steroid hormone homeostasis and gene expression in the hypothalamic–pituitary–gonadal axis of zebrafish</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>Bisphenol F (BPF) has been frequently detected in various environmental compartments, and previous studies found that BPF exhibits similar estrogenic and anti-androgenic effects on the mammalian endocrine system to those of bisphenol A (BPA). However, the potential disrupting effects of BPF on aquatic organisms and the underling disrupting mechanisms have not been investigated. In this study, the potential disrupting mechanisms of BPF on the hypothalamic–pituitary–gonadal (HPG) axis and liver were probed by employing the OECD 21-day short-term fecundity assay in zebrafish. The results show that BPF exposure (1 mg/L) impaired the reproductive function of zebrafish, as exemplified by alterations to testicular and ovarian histology of the treated zebrafish. Homogenate testosterone (T) levels in male zebrafish decreased in a concentration-dependent manner, and 17β-estradiol (E2) levels increased significantly when fish were exposed to 0.1 and 1 mg/L BPF. The real-time polymerase chain reaction was performed to examine gene expression in the HPG axis and liver. Hepatic vitellogenin expression was significantly upregulated in males, suggesting that BPF possesses estrogenic activity. The disturbed hormone balance was enhanced by the significant changes in gene expression along the HPG axis. These alterations suggest that BPF leads to adverse effects on the endocrine system of teleost fish, and that these effects were more prominent in males than in females.</description><subject>17β-Estradiol</subject><subject>Animals</subject><subject>Aquatic organisms</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Benzhydryl Compounds - toxicity</subject><subject>Bisphenol A</subject><subject>Compartments</subject><subject>Danio rerio</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Endocrine Disruptors - toxicity</subject><subject>Endocrine system</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Estrogenic activity</subject><subject>Fecundity</subject><subject>Female</subject><subject>Fish</subject><subject>Gene expression</subject><subject>Gene Expression - drug effects</subject><subject>Gonadal Steroid Hormones - genetics</subject><subject>Gonadal Steroid Hormones - metabolism</subject><subject>Gonads - drug effects</subject><subject>Gonads - metabolism</subject><subject>Histology</subject><subject>Homeostasis</subject><subject>Homeostasis - drug effects</subject><subject>Hypothalamo-Hypophyseal System - drug effects</subject><subject>Hypothalamo-Hypophyseal System - metabolism</subject><subject>Hypothalamus</subject><subject>Liver</subject><subject>Male</subject><subject>Males</subject><subject>Phenols - toxicity</subject><subject>Pituitary</subject><subject>Polymerase chain reaction</subject><subject>Research Article</subject><subject>Sex differences</subject><subject>Sex hormones</subject><subject>Testosterone</subject><subject>Vitellogenin</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollutants, Chemical - toxicity</subject><subject>Water Pollution Control</subject><subject>Xenoestrogens</subject><subject>Zebrafish</subject><subject>Zebrafish - 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Academic</collection><jtitle>Environmental science and pollution research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Qian</au><au>Yang, Xianhai</au><au>Liu, Jining</au><au>Ren, Wenjuan</au><au>Chen, Yingwen</au><au>Shen, Shubao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of BPF on steroid hormone homeostasis and gene expression in the hypothalamic–pituitary–gonadal axis of zebrafish</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>24</volume><issue>26</issue><spage>21311</spage><epage>21322</epage><pages>21311-21322</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>Bisphenol F (BPF) has been frequently detected in various environmental compartments, and previous studies found that BPF exhibits similar estrogenic and anti-androgenic effects on the mammalian endocrine system to those of bisphenol A (BPA). However, the potential disrupting effects of BPF on aquatic organisms and the underling disrupting mechanisms have not been investigated. In this study, the potential disrupting mechanisms of BPF on the hypothalamic–pituitary–gonadal (HPG) axis and liver were probed by employing the OECD 21-day short-term fecundity assay in zebrafish. The results show that BPF exposure (1 mg/L) impaired the reproductive function of zebrafish, as exemplified by alterations to testicular and ovarian histology of the treated zebrafish. Homogenate testosterone (T) levels in male zebrafish decreased in a concentration-dependent manner, and 17β-estradiol (E2) levels increased significantly when fish were exposed to 0.1 and 1 mg/L BPF. The real-time polymerase chain reaction was performed to examine gene expression in the HPG axis and liver. Hepatic vitellogenin expression was significantly upregulated in males, suggesting that BPF possesses estrogenic activity. The disturbed hormone balance was enhanced by the significant changes in gene expression along the HPG axis. These alterations suggest that BPF leads to adverse effects on the endocrine system of teleost fish, and that these effects were more prominent in males than in females.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28741210</pmid><doi>10.1007/s11356-017-9773-z</doi><tpages>12</tpages></addata></record> |
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| identifier | ISSN: 0944-1344 |
| ispartof | Environmental science and pollution research international, 2017-09, Vol.24 (26), p.21311-21322 |
| issn | 0944-1344 1614-7499 |
| language | eng |
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| source | ABI/INFORM Global (ProQuest); Springer Link |
| subjects | 17β-Estradiol Animals Aquatic organisms Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Benzhydryl Compounds - toxicity Bisphenol A Compartments Danio rerio Earth and Environmental Science Ecotoxicology Endocrine Disruptors - toxicity Endocrine system Environment Environmental Chemistry Environmental Health Environmental science Estrogenic activity Fecundity Female Fish Gene expression Gene Expression - drug effects Gonadal Steroid Hormones - genetics Gonadal Steroid Hormones - metabolism Gonads - drug effects Gonads - metabolism Histology Homeostasis Homeostasis - drug effects Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - metabolism Hypothalamus Liver Male Males Phenols - toxicity Pituitary Polymerase chain reaction Research Article Sex differences Sex hormones Testosterone Vitellogenin Waste Water Technology Water Management Water Pollutants, Chemical - toxicity Water Pollution Control Xenoestrogens Zebrafish Zebrafish - genetics Zebrafish - metabolism |
| title | Effects of BPF on steroid hormone homeostasis and gene expression in the hypothalamic–pituitary–gonadal axis of zebrafish |
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