Clinical and metabolic response to flaxseed oil omega-3 fatty acids supplementation in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial

Data on the effects of flaxseed oil omega-3 fatty acids supplementation on wound healing and metabolic status in subjects with diabetic foot ulcer (DFU) are scarce. This study was conducted to evaluate the effects of flaxseed oil omega-3 fatty acids supplementation on wound healing and metabolic sta...

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Published in:Journal of diabetes and its complications 2017-09, Vol.31 (9), p.1394-1400
Main Authors: Soleimani, Zahra, Hashemdokht, Fatemeh, Bahmani, Fereshteh, Taghizadeh, Mohsen, Memarzadeh, Mohammad Reza, Asemi, Zatollah
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers
Clinical trials
Cytokines
Diabetes
Diabetic foot
Diabetic Foot - diet therapy
Diabetic Foot - metabolism
Dietary Supplements
Double-Blind Method
Double-blind studies
Evidence-based medicine
Fatty acids
Fatty Acids, Omega-3 - administration & dosage
Fatty Acids, Omega-3 - pharmacology
Female
Fish oils
Foot diseases
Gene expression
Humans
Inflammation
Inflammatory markers
Insulin
Insulin metabolism
Insulin resistance
Leg ulcers
Linseed Oil - administration & dosage
Linseed Oil - pharmacology
Male
Metabolic status
Metabolism
Metabolome - drug effects
Middle Aged
Omega-3 fatty acids administration
Oxidative stress
Pathogenesis
Placebos
Tumor necrosis factor-TNF
Wound healing
Wound Healing - drug effects
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Summary:Data on the effects of flaxseed oil omega-3 fatty acids supplementation on wound healing and metabolic status in subjects with diabetic foot ulcer (DFU) are scarce. This study was conducted to evaluate the effects of flaxseed oil omega-3 fatty acids supplementation on wound healing and metabolic status in subjects with DFU. The current randomized, double-blind, placebo-controlled trial was conducted among 60 subjects (aged 40–85years old) with grade 3 DFU. Subjects were randomly allocated into two groups (30 subjects each group) to receive either 1000mg omega-3 fatty acids from flaxseed oil supplements or placebo twice a day for 12weeks. After the 12-week intervention, compared with the placebo, omega-3 fatty acids supplementation resulted in significant decreases in ulcer length (−2.0±2.3 vs. −1.0±1.1cm, P=0.03), width (−1.8±1.7 vs. −1.0±1.0cm, P=0.02) and depth (−0.8±0.6 vs. −0.5±0.5cm, P=0.01). Additionally, significant reductions in serum insulin concentrations (−4.4±5.5 vs. +1.4±8.3 μIU/mL, P=0.002), homeostasis model of assessment-estimated insulin resistance (−2.1±3.0 vs. +1.0±5.0, P=0.005) and HbA1c (−0.9±1.5 vs. −0.1±0.4%, P=0.01), and a significant rise in the quantitative insulin sensitivity check index (+0.01±0.01 vs. −0.005±0.02, P=0.002) were seen following supplementation with omega-3 fatty acids compared with the placebo. In addition, omega-3 fatty acids supplementation significantly decreased serum high sensitivity C-reactive protein (hs-CRP) (−25.5±31.5 vs. −8.2±18.9μg/mL, P=0.01), and significantly increased plasma total antioxidant capacity (TAC) (+83.5±111.7 vs. −73.4±195.5mmol/L, P
ISSN:1056-8727
1873-460X
DOI:10.1016/j.jdiacomp.2017.06.010