Delayed Results of Experimental Afobazole Therapy in Rats after Acute Myocardial Infarction

Delayed cardioprotective effects of anxiolytic Afobazole (15 mg/kg, intraperitoneally for 14 days) were evaluated using dynamic echocardiographic recordings on days 2, 15, 56, and 98 after experimental myocardial infarction modeling (rat model of acute myocardial ischemia). The cardiotropic activity...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2017-06, Vol.163 (2), p.180-183
Main Authors: Kryzhanovskii, S. A., Tsorin, I. B., Stolyaruk, V. N., Ionova, E. O., Vititnova, M. B.
Format: Article
Language:English
Subjects:
Animals
Anxiety
Benzimidazoles - therapeutic use
Biomedical and Life Sciences
Biomedicine
Cardiomyocytes
Cell Biology
Coronary artery bypass
Coronary heart disease
Echocardiography
General Pathology and Pathophysiology
Heart
Heart attacks
Heart diseases
Heart Failure - drug therapy
Heart Failure - physiopathology
Internal Medicine
Ischemia
Laboratory Medicine
Male
Morpholines - therapeutic use
Myocardial infarction
Myocardial Infarction - drug therapy
Myocardial Infarction - physiopathology
Myocardial ischemia
Pathology
Rats
Rodents
Stroke Volume - drug effects
Tranquilizing agents
Ventricle
Ventricular Function, Left - drug effects
Ventricular Function, Left - physiology
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Summary:Delayed cardioprotective effects of anxiolytic Afobazole (15 mg/kg, intraperitoneally for 14 days) were evaluated using dynamic echocardiographic recordings on days 2, 15, 56, and 98 after experimental myocardial infarction modeling (rat model of acute myocardial ischemia). The cardiotropic activity of Afobazole is assumed to be related to its agonistic effects on σ 1 receptor of cardiomyocytes. It was found that animals treated with Afobazole had no signs of heart failure by the end of observation, as evidenced by left ventricular ejection fraction.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-017-3761-7