Epigallocatechin gallate enhances treatment efficacy of oral nifedipine against pregnancy‐induced severe pre‐eclampsia: A double‐blind, randomized and placebo‐controlled clinical study

Summary What is known and objective Oral nifedipine is commonly used to treat pre‐eclampsia, one of the most severe complications during pregnancy, but its clinical efficacy is less than ideal. Epigallocatechin gallate (EGCG), a natural compound from green tea, could benefit cardiovascular health es...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical pharmacy and therapeutics 2018-02, Vol.43 (1), p.21-25
Main Authors: Shi, D.‐D., Guo, J.‐j., Zhou, L., Wang, N.
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Antihypertensive Agents - therapeutic use
Blood pressure
Blood Pressure - drug effects
Catechin - analogs & derivatives
Catechin - pharmacology
Clinical trials
Complications
Double-Blind Method
Double-blind studies
Epigallocatechin gallate
Female
Green tea
Humans
Hypertension
Neonates
Nifedipine
Nifedipine - therapeutic use
Pre-eclampsia
Pre-Eclampsia - drug therapy
Preeclampsia
Pregnancy
Pregnancy complications
Randomization
Secondary treatment
Side effects
Tea
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary What is known and objective Oral nifedipine is commonly used to treat pre‐eclampsia, one of the most severe complications during pregnancy, but its clinical efficacy is less than ideal. Epigallocatechin gallate (EGCG), a natural compound from green tea, could benefit cardiovascular health especially hypertension. We investigated the clinical efficacy of EGCG, when complemented with oral nifedipine, in treating pre‐eclampsia. Methods A total of 350 pregnant women with severe pre‐eclampsia were recruited and randomized to receive oral nifedipine, together with placebo (NIF+placebo) or EGCG (NIF+EGCG). The primary treatment outcome was the time needed to control blood pressure and interval time before a new hypertensive crisis, whereas the secondary treatment outcome was the number of treatment doses to effectively control blood pressure, maternal adverse effects and neonatal complications. Results and discussion Comparing NIF+EGCG group to NIF+placebo group, the time needed to control blood pressure was significantly shorter (NIF+EGCG 31.2±16.7 minutes, NIF+placebo 45.3±21.9 minutes; 95% CI 9.7‐18.5 minutes), whereas interval time before a new hypertensive crisis was significantly prolonged (NIF+EGCG 7.2±2.9 hours, NIF+placebo 4.1±3.7 hours; 95% CI 2.3‐3.9 hours), and the number of treatment dosages needed to effectively control blood pressure was also lower. Between the two treatment groups, no differences in incidence rates of maternal adverse effects or neonatal complications were observed. What is new and conclusions EGCG is both safe and effective in enhancing treatment efficacy of oral nifedipine against pregnancy‐induced severe pre‐eclampsia, but formal validation is required prior to its recommendation for use outside of clinical trials. Epigallocatechin gallate is both safe and effective in enhancing treatment efficacy of oral nifedipine against pregnancy induced severe preeclampsia but formal validation is required prior to its recommendation for use outside of clinical trials.
ISSN:0269-4727
1365-2710
DOI:10.1111/jcpt.12597