Multi-regulatory network of ROS: the interconnection of ROS, PGC-1 alpha, and AMPK-SIRT1 during exercise

Transcriptional factors are easily susceptible to any stimuli, including exercise. Exercise can significantly influence PGC-1 α and AMPK-SIRT1 pathway, as it is involved in the regulation of energy metabolism and mitochondrial biogenesis. Exercise is a major energy deprivation process by which many...

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Bibliographic Details
Published in:Journal of physiology and biochemistry 2017-11, Vol.73 (4), p.487-494
Main Authors: Thirupathi, Anand, de Souza, Claudio Teodoro
Format: Article
Language:English
Subjects:
Adenylate Kinase - metabolism
Animal Physiology
Animals
Antioxidants
Biomedical and Life Sciences
Biomedicine
Deprivation
Energy Metabolism
Energy requirements
Exercise
Human Physiology
Humans
Metabolism
Mini Review
Mitochondria
Nitric Oxide - physiology
Oxygen
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism
Physical exercise
Proteins
Reactive oxygen species
Reactive Oxygen Species - metabolism
SIRT1 protein
Sirtuin 1 - metabolism
Transcription factors
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Summary:Transcriptional factors are easily susceptible to any stimuli, including exercise. Exercise can significantly influence PGC-1 α and AMPK-SIRT1 pathway, as it is involved in the regulation of energy metabolism and mitochondrial biogenesis. Exercise is a major energy deprivation process by which many of transcription factors get tuned positively. However, how transcription factors help to boost the antioxidant defense system at cellular level is elusive. It is well known that physical exercise can induce reactive oxygen species, but how these reactive oxygen species can help to regulate multiple transcription factors during exercise is an important area to be discussed yet. This review mainly focuses on interconnecting role of PGC-1 α and AMPK-SIRT1 pathway during exercise and how these proteins are getting tuned by reactive oxygen species in exercise condition.
ISSN:1138-7548
1877-8755
DOI:10.1007/s13105-017-0576-y