Effects of high‐intensity aerobic interval training on cardiovascular disease risk in testicular cancer survivors: A phase 2 randomized controlled trial

BACKGROUND Testicular cancer survivors (TCS) have an increased risk of treatment‐related cardiovascular disease (CVD), which may limit their overall survival. We evaluated the effects of high‐intensity aerobic interval training (HIIT) on traditional and novel CVD risk factors and surrogate markers o...

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Bibliographic Details
Published in:Cancer 2017-10, Vol.123 (20), p.4057-4065
Main Authors: Adams, Scott C., DeLorey, Darren S., Davenport, Margie H., Stickland, Michael K., Fairey, Adrian S., North, Scott, Szczotka, Alexander, Courneya, Kerry S.
Format: Article
Language:English
Subjects:
Activation
Adult
Aerobics
Arteriosclerosis
Atherosclerosis
Biomarkers
Cancer
Cardiorespiratory fitness
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - physiopathology
Carotid Artery Diseases - epidemiology
Clinical trials
Comorbidity
Confidence intervals
Covariance
Disease control
Exercise
Exercise Test
Exercise Therapy
Health risk assessment
Health risks
High-Intensity Interval Training - methods
high‐intensity interval training
Humans
Hypogonadism - epidemiology
Inflammation
Lipoproteins, LDL - metabolism
Long-term effects
Luminous intensity
Male
Metabolic Syndrome - epidemiology
Middle Aged
Morbidity
Mortality
Nervous system
Obesity - epidemiology
Oncology
Oxygen Consumption
Parasympathetic nervous system
Parasympathetic Nervous System - physiopathology
Physical Fitness
Prehypertension - epidemiology
Risk analysis
Risk factors
Stiffness
Survival
Survivors
Testes
Testicular cancer
testicular neoplasms
Testicular Neoplasms - epidemiology
Testicular Neoplasms - rehabilitation
Training
Vascular Stiffness - physiology
Young Adult
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Summary:BACKGROUND Testicular cancer survivors (TCS) have an increased risk of treatment‐related cardiovascular disease (CVD), which may limit their overall survival. We evaluated the effects of high‐intensity aerobic interval training (HIIT) on traditional and novel CVD risk factors and surrogate markers of mortality in a population‐based sample of TCS. METHODS This phase 2 trial (ClinicalTrials.gov identifier NCT02459132) randomly assigned 63 TCS to usual care (UC) or 12 weeks of supervised HIIT (ie, alternating periods of vigorous‐intensity and light‐intensity aerobic exercise). The primary outcome was peak aerobic fitness (VO2peak) assessed via a treadmill‐based maximal cardiorespiratory exercise test. Secondary endpoints included CVD risk (eg, Framingham Risk Score), arterial health, parasympathetic nervous system function, and blood‐based biomarkers. RESULTS Postintervention VO2peak data were obtained for 61 participants (97%). HIIT participants attended 99% of the exercise sessions and achieved 98% of the target exercise intensity. Analysis of covariance demonstrated that HIIT was superior to UC for improving VO2peak (adjusted between‐group mean difference, 3.7 mL O2/kg/min; 95% confidence interval, 2.4‐5.1 [P
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.30859