Palladium-Catalyzed Transformations of Alkyl C–H Bonds

Palladium-Catalyzed Transformations of Alkyl C–H Bonds

This Review summarizes the advancements in Pd-catalyzed C­(sp3)–H activation via various redox manifolds, including Pd(0)/Pd­(II), Pd­(II)/Pd­(IV), and Pd­(II)/Pd(0). While few examples have been reported in the activation of alkane C–H bonds, many C­(sp3)–H activation/C–C and C–heteroatom bond form...

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Bibliographic Details
Published in:Chemical reviews 2017-07, Vol.117 (13), p.8754-8786
Main Authors: He, Jian, Wasa, Masayuki, Chan, Kelvin S. L, Shao, Qian, Yu, Jin-Quan
Format: Article
Language:eng
Subjects:
Activation
Alkanes
Carbon
Catalysis
Chemical bonds
Chemical elements
Chemical reactions
Chemistry
Hydrocarbons
Hydrogen bonds
Palladium
Regioselectivity
Selectivity
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Summary:This Review summarizes the advancements in Pd-catalyzed C­(sp3)–H activation via various redox manifolds, including Pd(0)/Pd­(II), Pd­(II)/Pd­(IV), and Pd­(II)/Pd(0). While few examples have been reported in the activation of alkane C–H bonds, many C­(sp3)–H activation/C–C and C–heteroatom bond forming reactions have been developed by the use of directing group strategies to control regioselectivity and build structural patterns for synthetic chemistry. A number of mono- and bidentate ligands have also proven to be effective for accelerating C­(sp3)–H activation directed by weakly coordinating auxiliaries, which provides great opportunities to control reactivity and selectivity (including enantioselectivity) in Pd-catalyzed C–H functionalization reactions.
ISSN:0009-2665
1520-6890