Occupational exposure to pesticides are associated with fixed airflow obstruction in middle-age

RationalePopulation-based studies have found evidence of a relationship between occupational exposures and Chronic Obstructive Pulmonary Disease (COPD), but these studies are limited by the use of prebronchodilator spirometry. Establishing this link using postbronchodilator is critical, because occu...

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Bibliographic Details
Published in:Thorax 2017-11, Vol.72 (11), p.990-997
Main Authors: Alif, Sheikh M, Dharmage, Shyamali C, Benke, Geza, Dennekamp, Martine, Burgess, John A, Perret, Jennifer L, Lodge, Caroline J, Morrison, Stephen, Johns, David Peter, Giles, Graham G, Gurrin, Lyle C, Thomas, Paul S, Hopper, John Llewelyn, Wood-Baker, Richard, Thompson, Bruce R, Feather, Iain H, Vermeulen, Roel, Kromhout, Hans, Walters, E Haydn, Abramson, Michael J, Matheson, Melanie Claire
Format: Article
Language:English
Subjects:
Adult
Chronic obstructive pulmonary disease
Female
Follow-Up Studies
Forced Expiratory Volume
Health risk assessment
Humans
Longitudinal Studies
Male
Middle Aged
Occupational Exposure - adverse effects
Pesticides
Pesticides - toxicity
Prevalence
Pulmonary Disease, Chronic Obstructive - chemically induced
Pulmonary Disease, Chronic Obstructive - epidemiology
Pulmonary Disease, Chronic Obstructive - physiopathology
Risk Factors
Smoking - adverse effects
Spirometry
Studies
Surveys and Questionnaires
Tasmania - epidemiology
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Summary:RationalePopulation-based studies have found evidence of a relationship between occupational exposures and Chronic Obstructive Pulmonary Disease (COPD), but these studies are limited by the use of prebronchodilator spirometry. Establishing this link using postbronchodilator is critical, because occupational exposures are a modifiable risk factor for COPD.ObjectivesTo investigate the associations between occupational exposures and fixed airflow obstruction using postbronchodilator spirometry.MethodsOne thousand three hundred and thirty-five participants were included from 2002 to 2008 follow-up of the Tasmanian Longitudinal Health Study (TAHS). Spirometry was performed and lifetime work history calendars were used to collect occupational history. ALOHA plus Job Exposure Matrix was used to assign occupational exposure, and defined as ever exposed and cumulative exposure unit (EU)-years. Fixed airflow obstruction was defined by postbronchodilator FEV1/FVC
ISSN:0040-6376
1468-3296
DOI:10.1136/thoraxjnl-2016-209665