Copper-catalyzed intermolecular asymmetric propargylic dearomatization of phenol derivatives

A copper-catalyzed intermolecular asymmetric propargylic dearomatization of phenol derivatives has been realized. Under the catalysis of Cu(OTf)·1/2C H decorated with a chiral tridentate ketimine P,N,N-ligand, the dearomatization reaction proceeded smoothly with excellent control of chemo-, regio-,...

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Published in:Chemical communications (Cambridge, England) England), 2017, Vol.53 (58), p.8192-8195
Main Authors: Shao, Long, Hu, Xiang-Ping
Format: Article
Language:English
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Summary:A copper-catalyzed intermolecular asymmetric propargylic dearomatization of phenol derivatives has been realized. Under the catalysis of Cu(OTf)·1/2C H decorated with a chiral tridentate ketimine P,N,N-ligand, the dearomatization reaction proceeded smoothly with excellent control of chemo-, regio-, and enantioselectivities, thus providing a variety of optically active cyclohexadienone derivatives with up to >99% ee.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc03034g