Serotonin, calcitonin and calcitonin gene-related peptide in acute pancreatitis

Objective: The aim of this study was to investigate plasma levels of serotonin, calcitonin and calcitonin gene-related peptide (CGRP) in the course of acute pancreatitis (AP) taking organ failure, etiology and severity into consideration. Material and methods: Sixty consecutive patients with alcohol...

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Bibliographic Details
Published in:Scandinavian journal of gastroenterology 2017-10, Vol.52 (10), p.1140-1147
Main Authors: Wahlstrøm, Kirsten Lykke, Novovic, Srdan, Ersbøll, Annette Kjær, Hasbak, Philip, Jørgensen, Lars Nannestad, Berner Hansen, Mark
Format: Article
Language:English
Subjects:
Acute Disease
Acute pancreatitis
Adult
Aged
Aged, 80 and over
Alcoholism - complications
Biomarkers - blood
calcitonin
Calcitonin - blood
calcitonin gene-related peptide
Calcitonin Gene-Related Peptide - blood
Case-Control Studies
coagulation
Female
Gallstones - complications
Humans
Male
microcirculation
Middle Aged
Pancreas - physiopathology
Pancreatitis - blood
Pancreatitis - etiology
Pancreatitis - physiopathology
Prospective Studies
serotonin
Serotonin - blood
Severity of Illness Index
Time Factors
vasoactive
Young Adult
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Summary:Objective: The aim of this study was to investigate plasma levels of serotonin, calcitonin and calcitonin gene-related peptide (CGRP) in the course of acute pancreatitis (AP) taking organ failure, etiology and severity into consideration. Material and methods: Sixty consecutive patients with alcohol- or gallstone-induced AP were included over a 15-month period. Patients were treated according to a standardized algorithm and monitored for organ specific morbidity and mortality. Organ functions and blood samples were assessed on days 0, 1, 2 and 14 after hospital admission. Twenty healthy volunteers, matched for age and gender, comprised the reference group. Results: Lower levels of serotonin were observed in patients at admission compared to healthy volunteers (p = .021). Serotonin levels increased from day 2 to 14 (p 
ISSN:0036-5521
1502-7708
DOI:10.1080/00365521.2017.1346703