The evaluation of non‐invasive multi‐slice spiral computed tomography‐based indices for the diagnosis and prognosis prediction of liver cirrhosis

OBJECTIVE This study aimed to evaluate easily available computed tomography (CT)‐based parameters for assessing the presence and severity of cirrhosis and predicting complications in Chinese patients with cirrhosis. METHODS CT‐based morphological indices were determined in 167 patients with cirrhosi...

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Bibliographic Details
Published in:Journal of digestive diseases 2017-08, Vol.18 (8), p.472-479
Main Authors: Feng, Ling Mei, Lei, Shu Juan, Zeng, Xin, Wang, Pei Qin, Chen, Ru Tan, Wang, Jian, Sheng, Xia, Shi, Pei Mei, Yuan, Zong Li, Xie, Wei Fen
Format: Article
Language:English
Subjects:
Adult
Aged
Cirrhosis
complication
Computed tomography
Correlation analysis
Diagnosis
Female
Humans
Liver
Liver - diagnostic imaging
Liver - pathology
Liver - physiopathology
Liver cirrhosis
Liver Cirrhosis - complications
Liver Cirrhosis - diagnostic imaging
Liver Cirrhosis - pathology
Liver Cirrhosis - physiopathology
liver function tests, splenic volume
Male
Middle Aged
Morphology
Organ Size
Prognosis
ROC Curve
Sensitivity and Specificity
Severity of Illness Index
Spleen
Spleen - diagnostic imaging
Spleen - pathology
Tomography, Spiral Computed - methods
total liver volume
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Summary:OBJECTIVE This study aimed to evaluate easily available computed tomography (CT)‐based parameters for assessing the presence and severity of cirrhosis and predicting complications in Chinese patients with cirrhosis. METHODS CT‐based morphological indices were determined in 167 patients with cirrhosis and 244 healthy volunteers. The correlation of morphological indices with Child–Pugh score and cirrhotic complications was analyzed using Spearman's correlation analysis. The area under the receiver operating characteristic curve (AUROC) was used to analyze the diagnostic performance of the indices. Sensitivity and specificity were determined. RESULTS Patients with cirrhosis had a lower total liver volume (TLV) and a larger total splenic volume (SV) than healthy individuals. There was a significant difference in the portal venous diameter, splenic venous diameter and portal venous cross‐sectional area between the two groups. A low TLV/SV ratio was strongly associated with liver cirrhosis; with a cut‐off value of 4.27 for the diagnosis of cirrhosis TLV/SV had a sensitivity of 87.7% and a specificity of 84.9%, and AUROC of 0.921. Further analysis showed that TLV/SV was accurate in discriminating between mild and moderate/severe cirrhosis and could be used for predicting complications of cirrhosis. CONCLUSION The easily available parameters of CT can accurately evaluate the severity of cirrhosis in Chinese patients.
ISSN:1751-2972
1751-2980
DOI:10.1111/1751-2980.12506