Late outcomes of pulmonary embolism: The post-PE syndrome

Abstract The post-Pulmonary Embolism (post-PE) syndrome is being increasingly recognized as a long-term consequence of PE. Its most severe manifestation, chronic thromboembolic pulmonary hypertension (CTEPH), affects a small proportion of PE survivors. However, many more with less severe post-PE syn...

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Bibliographic Details
Published in:Thrombosis research 2018-04, Vol.164, p.157-162
Main Authors: Sista, Akhilesh K, Klok, Frederikus A
Format: Article
Language:English
Subjects:
Chronic thromboembolic pulmonary hypertension
Hematology, Oncology and Palliative Medicine
Post-PE syndrome
Pulmonary embolism
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Summary:Abstract The post-Pulmonary Embolism (post-PE) syndrome is being increasingly recognized as a long-term consequence of PE. Its most severe manifestation, chronic thromboembolic pulmonary hypertension (CTEPH), affects a small proportion of PE survivors. However, many more with less severe post-PE syndrome have reduced quality of life and functional capacity. The pathophysiology is incompletely understood, but involves unresolved pulmonary artery thrombus, right ventricular damage, and abnormal gas exchange. Treatment has only been established for CTEPH, and further studies are required to determine if novel treatment and/or preventative strategies can reduce the incidence of this entity.
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2017.06.017