Latero-cervical lymph node metastases (N1b) represent an additional risk factor for papillary thyroid cancer outcome

Purpose Papillary thyroid carcinoma (PTC), the most common thyroid cancer histotype, has a good prognosis even when spread to the neck lymph node (LN). The prognostic role of LN metastases’ location is still controversial. The aim of the present study was to evaluate the clinical relevance of the nu...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2017-12, Vol.40 (12), p.1355-1363
Main Authors: Sapuppo, G., Palermo, F., Russo, M., Tavarelli, M., Masucci, R., Squatrito, S., Vigneri, R., Pellegriti, G.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Carcinoma, Papillary - secondary
Carcinoma, Papillary - surgery
Child
Endocrinology
Female
Follow-Up Studies
Humans
Lymph
Lymph nodes
Lymph Nodes - pathology
Lymph Nodes - surgery
Lymphatic Metastasis
Lymphatic system
Male
Mastectomy
Medicine
Medicine & Public Health
Metabolic Diseases
Metastases
Metastasis
Middle Aged
Neck
Neck Dissection
Original Article
Papillary thyroid cancer
Papillary thyroid carcinoma
Prognosis
Retrospective Studies
Risk Factors
Thyroid cancer
Thyroid Neoplasms - pathology
Thyroid Neoplasms - surgery
Thyroidectomy
Young Adult
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Summary:Purpose Papillary thyroid carcinoma (PTC), the most common thyroid cancer histotype, has a good prognosis even when spread to the neck lymph node (LN). The prognostic role of LN metastases’ location is still controversial. The aim of the present study was to evaluate the clinical relevance of the number and location of LN metastases at presentation in PTCs. Methods This retrospective study included a consecutive series of 1653 PTC patients followed for a mean period of 5.9 years in a referral thyroid cancer clinic. All patients have undergone thyroidectomy with the dissection of at least six LNs. According to the LN status, patients were subdivided into 569 N0 (34.4%), 644 N1a (39.0%, central compartment) and 440 N1b (26.6%, latero-cervical compartment). Results Age at diagnosis was significantly lower in N1b (39.8, IQR 30.7–51.6) and N1a (40.1, IQR 31.3–50.1) than in N0 (44.7, IQR 36.6–55.0 yrs). The male gender was more prevalent in N1b than in N1a and N0 (F/M = 1.9/1, 4.0/1 and 5.5/1, respectively). Persistent/recurrent disease at last control was significantly more frequent in N1b (29.8%) than in N1a (14.3%), and in N1a than in N0 (4.2%) ( p  
ISSN:1720-8386
0391-4097
1720-8386
DOI:10.1007/s40618-017-0714-y