Compound muscle action potential duration in critical illness neuromyopathy

ABSTRACT Introduction We sought to determine the specificity of compound muscle action potential (CMAP) durations and amplitudes in a large critical illness neuromyopathy (CINM) cohort relative to controls with other neuromuscular conditions. Methods Fifty‐eight patients with CINM who had been seen...

Full description

Saved in:
Bibliographic Details
Published in:Muscle & nerve 2018-03, Vol.57 (3), p.395-400
Main Authors: Kramer, Christopher L., Boon, Andrea J., Harper, C. Michel, Goodman, Brent P.
Format: Article
Language:English
Subjects:
Action potential
Amplitudes
compound muscle action potential amplitude
compound muscle action potential duration
critical illness myopathy
critical illness neuromyopathy
critical illness neuropathy
ICU acquired weakness
Muscles
Myopathy
nerve conduction study
Nerves
Patients
Peripheral neuropathy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT Introduction We sought to determine the specificity of compound muscle action potential (CMAP) durations and amplitudes in a large critical illness neuromyopathy (CINM) cohort relative to controls with other neuromuscular conditions. Methods Fifty‐eight patients with CINM who had been seen over a 17‐year period were retrospectively studied. Electrodiagnostic findings of the CINM cohort were compared with patients with axonal peripheral neuropathy and myopathy due to other causes. Results Mean CMAP durations were prolonged, and mean CMAP amplitudes were severely reduced both proximally and distally in all nerves studied in the CINM cohort relative to the control groups. The specificity of prolonged CMAP durations for CINM approached 100% if they were encountered in more than 1 nerve. Discussion Prolonged, low‐amplitude CMAPs occur more frequently and with greater severity in CINM patients than in neuromuscular controls with myopathy and axonal neuropathy and are highly specific for the diagnosis of CINM. Muscle Nerve 57: 395–400, 2018
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.25732