Synergism between Naproxen and Rutin in a Mouse Model of Visceral Pain

ABSTRACT Preclinical Research The aim of the present study was to evaluate the antinociceptive interaction between naproxen and the glycoside flavonoid, rutin in the acetic acid‐induced writhing test in mice. Naproxen (5, 20, 50, and 100 mg/kg p.o.) or rutin (10, 25, 50, and 100mg/kg p.o.) were admi...

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Published in:Drug development research 2017-08, Vol.78 (5), p.184-188
Main Authors: Alonso‐Castro, Angel Josabad, Rangel‐Velázquez, Joceline Estefanía, Isiordia‐Espinoza, Mario A., Villanueva‐Solís, Luis Enrique, Aragon‐Martinez, Othoniel H., Zapata‐Morales, Juan Ramón
Format: Article
Language:English
Subjects:
Acetic acid
Acetic Acid - adverse effects
acute visceral pain test
Administration, Oral
Analgesics - administration & dosage
Analgesics - pharmacology
Animals
Disease Models, Animal
Dose-Response Relationship, Drug
Drug interaction
Drug Synergism
Drug Therapy, Combination
Drugs
Humans
isobolographic analysis
Mice
Naproxen
Naproxen - administration & dosage
Naproxen - pharmacology
Pain
Pain Measurement - drug effects
Pain perception
Rodents
Rutin
Rutin - administration & dosage
Rutin - pharmacology
Synergism
Visceral Pain - chemically induced
Visceral Pain - drug therapy
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Summary:ABSTRACT Preclinical Research The aim of the present study was to evaluate the antinociceptive interaction between naproxen and the glycoside flavonoid, rutin in the acetic acid‐induced writhing test in mice. Naproxen (5, 20, 50, and 100 mg/kg p.o.) or rutin (10, 25, 50, and 100mg/kg p.o.) were administered 60 min before the intraperitoneal administration with acetic acid. The dose‐response curve of each individual compound and the experimental effective dose 50 (ED50) value were obtained to determinate different proportions of the combinations between the two compounds (naproxen‐rutin 1:1, 3:1, and 3:1) in the writhing test. The results indicated a synergistic antinociceptive interaction between two drugs with different mechanism of action, naproxen and rutin in all the combinations. Drug Dev Res 78 : 184–188, 2017. © 2017 Wiley Periodicals, Inc.
ISSN:0272-4391
1098-2299
DOI:10.1002/ddr.21391