Snake spectacle vessel permeability to sodium fluorescein

Objective Assess vascular permeability of the snake spectacle to sodium fluorescein during resting and shedding phases of the ecdysis cycle. Animal studied Ball python (Python regius). Procedures The snake was anesthetized, and spectral domain optic coherence tomography was performed prior to angiog...

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Bibliographic Details
Published in:Veterinary ophthalmology 2018-03, Vol.21 (2), p.119-124
Main Authors: Bellhorn, Roy W., Strom, Ann R., Motta, Monica J., Doval, John, Hawkins, Michelle G., Paul‐Murphy, Joanne
Format: Article
Language:English
Subjects:
Animals
ball python
Boidae - anatomy & histology
Boidae - metabolism
Capillary Permeability
ecdysis
Eye - blood supply
Eye - diagnostic imaging
Eye - metabolism
Female
Fluorescein - pharmacokinetics
fluorescein angiography
Fluorescein Angiography - methods
Fluorescein Angiography - veterinary
Fluorescent Dyes - pharmacokinetics
Iris - diagnostic imaging
Iris - metabolism
Molting
permeability
Python regius
snake spectacle
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Summary:Objective Assess vascular permeability of the snake spectacle to sodium fluorescein during resting and shedding phases of the ecdysis cycle. Animal studied Ball python (Python regius). Procedures The snake was anesthetized, and spectral domain optic coherence tomography was performed prior to angiographic procedures. An electronically controlled digital single‐lens reflex camera with a dual‐head flash equipped with filters suitable for fluorescein angiography was used to make images. Sodium fluorescein (10%) solution was administered by intracardiac injection. Angiographic images were made as fluorescein traversed the vasculature of the iris and spectacle. Individually acquired photographic frames were assessed and sequenced into pseudovideo image streams for further evaluation Conclusions Fluorescein angiograms of the snake spectacle were readily obtained. Vascular permeability varied with the phase of ecdysis. Copious leakage of fluorescein occurred during the shedding phase. This angiographic method may provide diverse opportunities to investigate vascular aspects of snake spectacle ecdysis, dysecdysis, and the integument in general.
ISSN:1463-5216
1463-5224
DOI:10.1111/vop.12483