Hemophagocytic lymphohistiocytosis associated to Haemophilus parainfluenzae endocarditis- a case report

Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe and potentially fatal syndrome that is characterized by increased proliferation and activation of benign macrophages with hemophagocytosis throughout the reticuloendothelial system. This syndrome is classified as primary (genetic) or seco...

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Bibliographic Details
Published in:Acta clinica belgica (English ed. Online) 2018-06, Vol.73 (3), p.220-223
Main Authors: Costescu Strachinaru, D I, Chaumont, M, Gobin, D, Sattar, L, Strachinaru, M, Karakike, E, Roman, A, Konopnicki, D
Format: Article
Language:English
Subjects:
Adult
Brain - diagnostic imaging
Brain - pathology
Case reports
Endocarditis
Endocarditis, Bacterial
Haemophilus Infections
Haemophilus parainfluenzae
Heart - diagnostic imaging
Humans
Lymphatic diseases
Lymphohistiocytosis, Hemophagocytic
Male
Myocardium - pathology
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Description
Summary:Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe and potentially fatal syndrome that is characterized by increased proliferation and activation of benign macrophages with hemophagocytosis throughout the reticuloendothelial system. This syndrome is classified as primary (genetic) or secondary when acquired in the context of infections (usually viral), malignancies, rheumatologic and metabolic diseases. We report a case of HLH complicating a Haemophilus parainfluenzae mitral valve endocarditis and resolving under antibiotic and surgical treatment alone. We also review other case reports of infective endocarditis associated with HLH. The syndrome is probably underdiagnosed. To our knowledge, this is the first report of a HLH syndrome associated with H. parainfluenzae endocarditis.
ISSN:1784-3286
2295-3337
DOI:10.1080/17843286.2017.1341691