Neuronal substrates of sleep homeostasis; lessons from flies, rats and mice

Highlights • Potassium channel dynamics control excitability of sleep-promoting neurons in flies. • The Drosophila ellipsoid body and dorsal fan-shaped body interact to drive sleep homeostasis. • Astrocyte-derived adenosine links cellular metabolism and sleep homeostasis in rodents. • Adenosine both...

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Bibliographic Details
Published in:Current opinion in neurobiology 2017-06, Vol.44, p.228-235
Main Authors: Donlea, Jeffrey M, Alam, Md Noor, Szymusiak, Ronald
Format: Article
Language:English
Subjects:
Neurology
Psychiatry
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Summary:Highlights • Potassium channel dynamics control excitability of sleep-promoting neurons in flies. • The Drosophila ellipsoid body and dorsal fan-shaped body interact to drive sleep homeostasis. • Astrocyte-derived adenosine links cellular metabolism and sleep homeostasis in rodents. • Adenosine both suppresses wake-promoting neuronal systems and excites sleep promoting neurons. • Opponent actions of wake-promoting and sleep promoting neurons occur in flies and rodents.
ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2017.05.003