Autonomic nervous system function in adolescent migraineurs

Background Migraine is a common and disabling neurological disorder. Studies on the relationship between migraine and the autonomic nervous system (ANS) have been inconclusive. Moreover, pediatric studies are extremely limited. Therefore, the present study investigated interictal ANS function in ado...

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Bibliographic Details
Published in:Pediatrics international 2017-09, Vol.59 (9), p.991-995
Main Authors: Yoshida, Seiji, Tanaka, Hidetaka, Mizutani, Midori, Nakao, Ryota, Okamoto, Naoyuki, Kajiura, Mitsugu, Kanbara, Yukiko, Tamai, Hiroshi
Format: Article
Language:English
Subjects:
active standing test
Adolescent
Autonomic nervous system
Autonomic Nervous System - physiopathology
autonomic nervous system function
beat‐to‐beat blood pressure monitoring
Blood pressure
Blood Pressure - physiology
Case-Control Studies
Child
Female
Headache
Heart rate
Heart Rate - physiology
heart rate variability
Humans
Male
Migraine
Migraine Disorders - physiopathology
Nervous system
Pediatrics
Pressure measurement
Spectral analysis
Supine position
Variability
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Summary:Background Migraine is a common and disabling neurological disorder. Studies on the relationship between migraine and the autonomic nervous system (ANS) have been inconclusive. Moreover, pediatric studies are extremely limited. Therefore, the present study investigated interictal ANS function in adolescent migraineurs. Methods We studied 21 patients with migraine and 26 healthy controls. Beat‐to‐beat blood pressure (BP) and heart rate (HR) were non‐invasively and continuously measured in the supine and standing positions. ANS function was evaluated on power spectral analysis of HR variability and diastolic BP (DBP) variability. Results Heart rate and systolic BP were not different between the two groups in either the supine or standing position. DBP did not differ between groups in the standing position, but was significantly higher in migraineurs in the supine position. The vasoconstrictor index was significantly higher in migraineurs. High‐frequency (HF) RR interval variability (RR‐HF) and the ratio of the low‐frequency (LF) to HF component of RR interval variability (RR‐LF/HF) were not different between the two groups in both positions. The LF component of DBP variability (DBP‐LF) in the supine position was significantly lower in migraineurs, while DBP‐LF during standing in migraineurs was significantly higher than in controls. Conclusion Migraineurs have significantly lower sympathetic vasomotor activity in the supine position, while sympathetic vasomotor activity was hyperresponsive during standing.
ISSN:1328-8067
1442-200X
DOI:10.1111/ped.13342