Lipid-rich enteral nutrition controls intestinal inflammation, improves intestinal motility and mucosal barrier damage in a rat model of intestinal ischemia/reperfusion injury

Abstract Background It has been reported that lipid-rich enteral nutrition (EN) could ameliorate inflammation in various diseases. In this study, we investigated whether lipid-rich EN could control intestinal inflammation, improve intestinal motility and mucosal barrier injury after intestinal ische...

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Bibliographic Details
Published in:The Journal of surgical research 2017-06, Vol.213, p.75-83
Main Authors: Lin, Zhi-Liang, MD, PhD, Tan, Shan-Jun, MD, PhD, Cheng, Min-hua, MD, PhD, Zhao, Chen-Yan, MD, PhD, Yu, Wen-Kui, MD, PhD, He, Yu-long, MD, PhD, Li, Jieshou, MD, Li, Ning, MD
Format: Article
Language:English
Subjects:
Animal experiment
Animals
Biomarkers - metabolism
Enteral Nutrition - methods
Food, Formulated
Gastrointestinal Motility - physiology
Inflammation - etiology
Inflammation - metabolism
Inflammation - pathology
Inflammation - prevention & control
Intestinal inflammation
Intestinal ischemia/reperfusion injury
Intestinal motility
Intestinal Mucosa - metabolism
Intestinal Mucosa - pathology
Intestinal Mucosa - physiopathology
Intestinal mucosal barrier
Lipid-rich enteral nutrition
Lipids - therapeutic use
Male
Permeability
Random Allocation
Rats
Rats, Sprague-Dawley
Reperfusion Injury - metabolism
Reperfusion Injury - pathology
Reperfusion Injury - physiopathology
Reperfusion Injury - therapy
Surgery
Tight Junctions - metabolism
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Summary:Abstract Background It has been reported that lipid-rich enteral nutrition (EN) could ameliorate inflammation in various diseases. In this study, we investigated whether lipid-rich EN could control intestinal inflammation, improve intestinal motility and mucosal barrier injury after intestinal ischemia/reperfusion (I/R) injury. Methods Male adult rats received saline, conventional EN, or lipid-rich EN via gavage before and after intestinal I/R injury. The superior mesenteric artery was occluded for 60 min. The sham group underwent laparotomy without superior mesenteric artery occlusion and was administrated saline. Intestinal motility was measured 4 h after intestinal I/R injury by FITC-Dextran transit assay; the intestinal and systemic inflammation were assessed by analyzing intestinal and serum concentrations of tumor necrosis factor α, interleukin (IL)- 6, and IL-10, separately. The intestinal mucosal barrier injury was assessed by analyzing the serum levels of intestinal fatty acid–binding protein (I-FABP) and intestinal mucosal tight junction (TJ) proteins. Results The intestinal I/R injury decreased intestinal motility and intestinal mucosal TJs expression significantly when compared with the sham group ( P  
ISSN:0022-4804
1095-8673
DOI:10.1016/j.jss.2017.02.007