Severe hypoglycaemia among patients with type 2 diabetes requiring emergency hospital admission: The Hypoglycaemia In Portugal Observational Study–Emergency Room (HIPOS–ER)

Aims To analyse the prevalence of severe hypoglycaemia in patients with type 2 diabetes (T2DM) treated with antihyperglycaemic agents (AHA) and requiring emergency room (ER) assistance, and to analyse the prevalence according to type of AHA therapy. Methods The present study, the Hypoglycaemia In Po...

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Bibliographic Details
Published in:Diabetes, obesity & metabolism obesity & metabolism, 2018-01, Vol.20 (1), p.50-59
Main Authors: Conceição, João, Dores, Jorge, Araújo, Francisco, Laires, Pedro A., Carr, Richard D., Brodovicz, Kimberly, Radican, Larry, Nogueira, Ana M.
Format: Article
Language:English
Subjects:
Aged
Antidiabetics
Combined Modality Therapy - adverse effects
Cross-Sectional Studies
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - diet therapy
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - mortality
Diet, Diabetic - adverse effects
Drug Therapy, Combination - adverse effects
Elder Nutritional Physiological Phenomena - drug effects
emergency department
Emergency medical care
Emergency Service, Hospital
Female
Hospitalization
Humans
hypoglycaemia
Hypoglycemia
Hypoglycemia - chemically induced
Hypoglycemia - epidemiology
Hypoglycemia - physiopathology
Hypoglycemia - therapy
Hypoglycemic Agents - adverse effects
Hypoglycemic Agents - therapeutic use
Incretins - adverse effects
Incretins - therapeutic use
Insulin
Insulin - adverse effects
Insulin - metabolism
Insulin - therapeutic use
Insulin Secretion
Length of Stay
Male
Middle Aged
Observational studies
Patient Compliance
Portugal - epidemiology
Prevalence
Primary care
Risk
Severity of Illness Index
Syncope
Syncope - etiology
type 2 diabetes
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Summary:Aims To analyse the prevalence of severe hypoglycaemia in patients with type 2 diabetes (T2DM) treated with antihyperglycaemic agents (AHA) and requiring emergency room (ER) assistance, and to analyse the prevalence according to type of AHA therapy. Methods The present study, the Hypoglycaemia In Portugal Observational Study–Emergency Room (HIPOS–ER), was a cross‐sectional, observational, multicentre, nationwide study, with specific hypoglycaemia source data collection. Results Within the study period, a total of 425 706 admissions were recorded in the ERs of participating hospitals. The prevalence of severe hypoglycaemic episodes in patients with T2DM was 0.074%. In all, 238 patients were included, more than half of whom were on insulin‐based therapy (55.0%) and a third of whom (31.5%) were on oral secretagogue‐based therapy. In 61.2% of patients primary care was the main diabetes care setting. The median patient age was 77.5 years and the mean duration of diabetes was 19 years. Missing a meal or low carbohydrate meal content was the most frequent cause of hypoglycaemia (55.9%) and the most frequent triggers for seeking emergency assistance were pre‐syncope (19.2%) and transient loss of consciousness (17.4%). A total of 44.1% of patients were hospitalized for a median of 5.1 days. Patients in the secretagogue group were admitted to hospital more often than patients in the insulin group (70.7% vs 29.0%; P 
ISSN:1462-8902
1463-1326
DOI:10.1111/dom.13030