Autoimmune comorbidity in achalasia patients

Idiopathic achalasia is a rare esophageal motor disorder. The disease state manifests local and systemic inflammation, and it appears that an autoimmune component and specific autoantibodies participate in the pathogenesis. The study aims to determine the prevalence of autoimmune and chronic inflamm...

Full description

Saved in:
Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2018-01, Vol.33 (1), p.203-208
Main Authors: Romero-Hernández, Fernanda, Furuzawa-Carballeda, Janette, Hernández-Molina, Gabriela, Alejandro-Medrano, Edgar, Núñez-Álvarez, Carlos A, Hernández-Ramírez, Diego F, Azamar-Llamas, Daniel, Olivares-Martínez, Elizabeth, Breña, Blanca, Palacios, Axel, Valdovinos, Miguel A, Coss-Adame, Enrique, Ramos-Ávalos, Bárbara, Torres-Landa, Samuel, Hernández-Ávila, Axel A, Flores-Nájera, Athenea, Torres-Villalobos, Gonzalo
Format: Article
Language:English
Subjects:
Achalasia
Autoantibodies
Autoimmune diseases
Esophagus
Gastroesophageal reflux
Hypothyroidism
Inflammatory diseases
Medical records
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Idiopathic achalasia is a rare esophageal motor disorder. The disease state manifests local and systemic inflammation, and it appears that an autoimmune component and specific autoantibodies participate in the pathogenesis. The study aims to determine the prevalence of autoimmune and chronic inflammatory diseases in patients with achalasia and compare the results with those from patients with gastroesophageal reflux disease (GERD). It was a cross-sectional and included 114 patients with idiopathic achalasia and 114 age-matched and sex-matched control patients with GERD. Data on the presence of autoimmune and inflammatory diseases, the time of presentation, and any family history of autoimmune disease were obtained from the hospital's medical records. Seventy three (64%) were female patients (mean age: 42.3 ± 15.5; median disease duration: 12 months). We identified the presence of autoimmune disease in 19 patients with achalasia (16.7%), hypothyroidism was the main diagnosis, and it was present in 52.6% of patients compared with 4.2% in controls. Thirteen of the 19 achalasia patients (68.4%) with autoimmune disease had history of familial autoimmunity. We identified 11 achalasia (9.6%) and 5 GERD patients (4.16%) with an inflammatory condition. Compared with the GERD, the achalasia group was 3.8 times more likely to have an autoimmune disease (95% CI: 1.47-9.83), 3.0 times more likely to have thyroidopathies (95% CI: 1.00-9.03), and 3.02 times more likely to suffer from any chronic inflammatory disease (95% CI: 1.65-6.20). The non-negligible number of patients with autoimmune diseases identified among the patients with idiopathic achalasia supports the hypothesis that achalasia has an autoimmune component.
ISSN:0815-9319
1440-1746
DOI:10.1111/jgh.13839