Electrospun Nanofibers of Curdlan (β‐1,3 Glucan) Blend as a Potential Skin Scaffold Material

Curdlan (β‐1,3 glucan) (7 wt%) with polyvinyl alcohol (PVA) (10 wt%) is blended at 1:2 weight ratio and electrospun to get nanofibers and is crosslinked with glutaraldehyde vapor to make it insoluble in water. It has a fiber diameter of less than 100 nm and is hydrophilic (contact angle = 35°). It i...

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Bibliographic Details
Published in:Macromolecular materials and engineering 2017-04, Vol.302 (4), p.np-n/a
Main Authors: Basha, Rubaiya Yunus, Sampath Kumar, T. S., Doble, Mukesh
Format: Article
Language:English
Subjects:
Blends
curdlan
Electrospinning
Glucan
nanofibers
Nanostructure
Polyvinyl alcohols
scaffold
Scaffolds
Scanning electron microscopy
Wound healing
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Summary:Curdlan (β‐1,3 glucan) (7 wt%) with polyvinyl alcohol (PVA) (10 wt%) is blended at 1:2 weight ratio and electrospun to get nanofibers and is crosslinked with glutaraldehyde vapor to make it insoluble in water. It has a fiber diameter of less than 100 nm and is hydrophilic (contact angle = 35°). It is biodegradable (10% in 14 d) and also has a good swelling behavior (≈170%). More than 100% of L6 cells are viable on this scaffold after 3 d. The scanning electron microscope images also reveal that cells are able to attach and spread in the nanofibrous scaffolds. In vitro scratch assay indicates that the wound closure rate of curdlan/PVA scaffold is better than PVA scaffold probably due to the immunomodulatory properties of the biopolymer. Thus our results indicate that curdlan/PVA scaffold can be an ideal material for wound healing applications. A nanofibrous scaffold of curdlan/poly(vinyl alcohol) blend is prepared by electrospinning technique. Cells cultured over the scaffold are able to attach and spread well and an increase in cell viability is also observed after 3 days. The presence of curdlan enhances the wound healing effect of the scaffold making it a promising material for wound healing applications.
ISSN:1438-7492
1439-2054
DOI:10.1002/mame.201600417