Evaluation of end-tidal CO2 pressure at the anaerobic threshold for detecting and assessing pulmonary hypertension

Cardiopulmonary exercise testing (CPET) is useful for the evaluation of patients with suspected or confirmed pulmonary hypertension (PH). End-tidal carbon dioxide pressure (PETCO 2 ) during exercise is reduced with elevated pulmonary artery pressure. However, the utility of ventilatory parameters su...

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Bibliographic Details
Published in:Heart and vessels 2017-11, Vol.32 (11), p.1350-1357
Main Authors: Higashi, Akifumi, Dohi, Yoshihiro, Yamabe, Sayuri, Kinoshita, Hiroki, Sada, Yoshiharu, Kitagawa, Toshiro, Hidaka, Takayuki, Kurisu, Satoshi, Yamamoto, Hideya, Yasunobu, Yuji, Kihara, Yasuki
Format: Article
Language:English
Subjects:
Biomedical Engineering and Bioengineering
Blood pressure
Carbon dioxide
Cardiac Surgery
Cardiology
Catheterization
Diagnostic systems
Echocardiography
Evaluation
Heart
Hypertension
Medicine
Medicine & Public Health
Multiple regression analysis
Original Article
Patients
Pulmonary arteries
Pulmonary artery
Pulmonary hypertension
Regression analysis
Sensitivity
Sensitivity analysis
Vascular Surgery
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Summary:Cardiopulmonary exercise testing (CPET) is useful for the evaluation of patients with suspected or confirmed pulmonary hypertension (PH). End-tidal carbon dioxide pressure (PETCO 2 ) during exercise is reduced with elevated pulmonary artery pressure. However, the utility of ventilatory parameters such as CPET for detecting PH remains unclear. We conducted a review in 155 patients who underwent right heart catheterization and CPET. Fifty-nine patients had PH [mean pulmonary arterial pressure (mPAP) ≥25 mmHg]. There was an inverse correlation between PETCO 2 at the anaerobic threshold (AT) and mPAP ( r  = −0.66; P  
ISSN:0910-8327
1615-2573
DOI:10.1007/s00380-017-0999-y