High hair cortisol concentrations predict worse cognitive outcome after stroke: Results from the TABASCO prospective cohort study

Highlights • Higher hair cortisol concentrations were significantly associated with a larger lesion volume. • Higher hair cortisol concentrations were significantly associated with worse cognitive results 6, 12 and 24 months post-stroke. • Individuals with higher long-term cortisol release (higher h...

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Published in:Psychoneuroendocrinology 2017-08, Vol.82, p.133-139
Main Authors: Ben Assayag, E, Tene, O, Korczyn, A.D, Shopin, L, Auriel, E, Molad, J, Hallevi, H, Kirschbaum, C, Bornstein, N.M, Shenhar-Tsarfaty, S, Kliper, E, Stalder, T
Format: Article
Language:English
Subjects:
Aged
Brain - pathology
Brain Ischemia - complications
Brain Ischemia - metabolism
Cognition - physiology
Cognition Disorders - complications
Cognition Disorders - pathology
Cognitive Dysfunction - pathology
Cohort Studies
Dementia
Endocrinology & Metabolism
Female
Hair - chemistry
Hair cortisol concentrations
Humans
Hydrocortisone - analysis
Ischemic Attack, Transient - complications
Ischemic Attack, Transient - metabolism
Israel
Longitudinal Studies
Male
Middle Aged
Neuropsychological Tests
Post-stroke cognitive decline
Predictive Value of Tests
Prospective Studies
Psychiatry
Risk Factors
Stroke - complications
Stroke - metabolism
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Summary:Highlights • Higher hair cortisol concentrations were significantly associated with a larger lesion volume. • Higher hair cortisol concentrations were significantly associated with worse cognitive results 6, 12 and 24 months post-stroke. • Individuals with higher long-term cortisol release (higher hair cortisol concentration) are prone to cognitive decline following an acute stroke or transient ischemic attack. • High HCC possibly modulate the response to cerebral ischemia and may serve as a preclinical marker of dementia.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2017.05.013