Direct Actions of Macronutrient Components on Goldfish Hepatopancreas In Vitro to Modulate the Expression of ghr-I , ghr-II , igf-I and igf-II mRNAs

Highlights • Glucose and tryptophan upregulate the expression of ghr-I; ghr-II; igf-I and igf-II. • Fatty acid’s unsaturation level modulates the ghr-I and ghr-II expression. • Fatty acids increase the igf-I expression and modulate the expression of igf-II. • We report GH-independent, direct effects...

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Bibliographic Details
Published in:General and comparative endocrinology 2017-09, Vol.250, p.1-8
Main Authors: Bertucci, Juan Ignacio, Blanco, Ayelén Melisa, Canosa, Luis Fabián, Unniappan, Suraj
Format: Article
Language:English
Subjects:
Animals
Diet
Endocrinology & Metabolism
Fatty acid
Fatty Acids - pharmacology
Gene Expression Regulation - drug effects
Glucose
Glucose - pharmacology
Goldfish - genetics
Growth hormone receptor
Hepatopancreas - drug effects
Hepatopancreas - metabolism
Insluline-like growth factor
Insulin-Like Growth Factor I - genetics
Insulin-Like Growth Factor I - metabolism
Insulin-Like Growth Factor II - genetics
Insulin-Like Growth Factor II - metabolism
Metabolism
Receptors, Somatotropin - genetics
Receptors, Somatotropin - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
Tryptophan
Tryptophan - pharmacology
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Summary:Highlights • Glucose and tryptophan upregulate the expression of ghr-I; ghr-II; igf-I and igf-II. • Fatty acid’s unsaturation level modulates the ghr-I and ghr-II expression. • Fatty acids increase the igf-I expression and modulate the expression of igf-II. • We report GH-independent, direct effects of macronutrients on GHR and IGF in fish.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2017.05.014