Synaptic Plasticity, Engrams, and Network Oscillations in Amygdala Circuits for Storage and Retrieval of Emotional Memories

The neuronal circuits of the basolateral amygdala (BLA) are crucial for acquisition, consolidation, retrieval, and extinction of associative emotional memories. Synaptic plasticity in BLA neurons is essential for associative emotional learning and is a candidate mechanism through which subsets of BL...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2017-05, Vol.94 (4), p.731-743
Main Authors: Bocchio, Marco, Nabavi, Sadegh, Capogna, Marco
Format: Article
Language:English
Subjects:
Activation
Amygdala
Amygdala - physiology
Animals
Appetitive Behavior
Association Learning - physiology
Associative learning
Associative memory
Auditory pathways
Axons
Basolateral Nuclear Complex - physiology
Brain Waves - physiology
Cerebral Cortex - physiology
Circuits
Circular dichroism
Cognitive ability
Conditioning
Conditioning (Psychology) - physiology
Consolidation
Defensive behavior
Delta Rhythm - physiology
Emotional behavior
Emotions - physiology
engrams
Fear
Fear - physiology
Gamma Rhythm - physiology
Genetics
Hippocampus
Human behavior
Humans
interneurons
Long-term depression
Long-term potentiation
Long-Term Potentiation - physiology
Memory
Memory - physiology
Mental disorders
Mental Recall
Motivation
Nerve Net
Neural Pathways
Neuronal Plasticity - physiology
Neurons
Oscillations
Prefrontal cortex
Primates
Protocol (computers)
Reinforcement
Rodents
Sensory stimuli
Somatosensory cortex
Stellar mass
Stimulation
Synapses
synaptic plasticity
Temporal lobe
Thalamus - physiology
Theta Rhythm - physiology
Visual cortex
Visual perception
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Description
Summary:The neuronal circuits of the basolateral amygdala (BLA) are crucial for acquisition, consolidation, retrieval, and extinction of associative emotional memories. Synaptic plasticity in BLA neurons is essential for associative emotional learning and is a candidate mechanism through which subsets of BLA neurons (commonly termed “engram”) are recruited during learning and reactivated during memory retrieval. In parallel, synchronous oscillations in the theta and gamma bands between the BLA and interconnected structures have been shown to occur during consolidation and retrieval of emotional memories. Understanding how these cellular and network phenomena interact is vital to decipher the roles of emotional memory formation and storage in the healthy and pathological brain. Here, we review data on synaptic plasticity, engrams, and network oscillations in the rodent BLA. We explore mechanisms through which synaptic plasticity, engrams, and long-range synchrony might be interconnected. Bocchio et al. review how synaptic plasticity, engrams, and network oscillations in amygdala circuits contribute to the encoding of emotional memories. They explore mechanisms through which these cellular and network phenomena could interact.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2017.03.022