Volatile Organic Compounds in Exhaled Breath of Idiopathic Pulmonary Fibrosis for Discrimination from Healthy Subjects

Purpose Human breath analysis is proposed with increasing frequency as a useful tool in clinical application. We performed this study to find the characteristic volatile organic compounds (VOCs) in the exhaled breath of patients with idiopathic pulmonary fibrosis (IPF) for discrimination from health...

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Bibliographic Details
Published in:Lung 2017-04, Vol.195 (2), p.247-254
Main Authors: Yamada, Yu-ichi, Yamada, Gen, Otsuka, Mitsuo, Nishikiori, Hirotaka, Ikeda, Kimiyuki, Umeda, Yasuaki, Ohnishi, Hirofumi, Kuronuma, Koji, Chiba, Hirofumi, Baumbach, Jörg Ingo, Takahashi, Hiroki
Format: Article
Language:English
Subjects:
Acetoin - analysis
Adult
Aged
Aged, 80 and over
Benzene Derivatives - analysis
Biomarkers
Breath Tests
Butadienes - analysis
Case-Control Studies
Female
Healthy Volunteers
Hemiterpenes - analysis
Humans
Idiopathic Pulmonary Fibrosis - diagnosis
Idiopathic Pulmonary Fibrosis - physiopathology
Interstitial Lung Disease
Male
Medicine
Medicine & Public Health
Middle Aged
Monoterpenes - analysis
Mucin-1 - blood
Oxygen - blood
Partial Pressure
Pentanes - analysis
Pneumology/Respiratory System
Pulmonary Diffusing Capacity
Pulmonary fibrosis
Vital Capacity
VOCs
Volatile organic compounds
Volatile Organic Compounds - analysis
Young Adult
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Summary:Purpose Human breath analysis is proposed with increasing frequency as a useful tool in clinical application. We performed this study to find the characteristic volatile organic compounds (VOCs) in the exhaled breath of patients with idiopathic pulmonary fibrosis (IPF) for discrimination from healthy subjects. Methods VOCs in the exhaled breath of 40 IPF patients and 55 healthy controls were measured using a multi-capillary column and ion mobility spectrometer. The patients were examined by pulmonary function tests, blood gas analysis, and serum biomarkers of interstitial pneumonia. Results We detected 85 VOC peaks in the exhaled breath of IPF patients and controls. IPF patients showed 5 significant VOC peaks; p-cymene, acetoin, isoprene, ethylbenzene, and an unknown compound. The VOC peak of p-cymene was significantly lower ( p  
ISSN:0341-2040
1432-1750
DOI:10.1007/s00408-017-9979-3