Demodex mites in acne rosacea: reflectance confocal microscopic study

Background/Objectives Demodex mite density is emphasised in the aetiopathogenesis of acne rosacea. Reflectance confocal microscopy (RCM) has been shown to be a good method for determining demodex mite density. The objective was to determine demodex mite density using RCM in acne rosacea patients and...

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Bibliographic Details
Published in:Australasian journal of dermatology 2017-05, Vol.58 (2), p.e26-e30
Main Authors: Turgut Erdemir, Asli, Gurel, Mehmet Salih, Koku Aksu, Ayse Esra, Falay, Tugba, Inan Yuksel, Esma, Sarikaya, Ebru
Format: Article
Language:English
Subjects:
Acne
Adult
Animals
Case-Control Studies
Cheek
Confocal microscopy
Demodex
Female
Follicles
Hair Follicle - diagnostic imaging
Hair Follicle - parasitology
Hair loss
Humans
Male
Microscopy, Confocal
Middle Aged
Mite Infestations - complications
Mite Infestations - diagnostic imaging
Mites
Reflectance
Rosacea
Rosacea - diagnostic imaging
Rosacea - parasitology
Scanning
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Summary:Background/Objectives Demodex mite density is emphasised in the aetiopathogenesis of acne rosacea. Reflectance confocal microscopy (RCM) has been shown to be a good method for determining demodex mite density. The objective was to determine demodex mite density using RCM in acne rosacea patients and compare them with controls. Methods In all, 30 papulopustular rosacea (PPR) and 30 erythematotelangiectatic rosacea (ETR) totally 60 acne rosacea patients and 40 controls, were enrolled in the study. The right cheek was selected for imaging and RCM was used for scanning. Ten images of 1000 × 1000 μm (total 10 mm2) area were scanned from adjacent areas. The numbers of follicles, infested follicles and mites were counted. The mean numbers of mites per follicle and infested follicles were calculated and compared in the patients and control groups. Results The mean number of mites was 44.30 ± 23.22 in PPR, 14.57 ± 15.86 in ETR and 3.55 ± 6.48 in the control group (P < 0.001). The mean number of mites per follicle was 1.77 ± 0.90 in PPR, 0.57 ± 0.63 in ETR and 0.13 ± 0.23 in the control group (P < 0.001). The cut‐off for the mean number of mites for determining mite infestation was 0.17 and above. Conclusions Demodex mite density was markedly increased in both ETR and PPR patients. It is believed that the presence of demodex mites plays an important role in rosacea aetiopathogenesis. Demodex mite treatment may reduce the severity of the disease and slow its progressive nature.
ISSN:0004-8380
1440-0960
DOI:10.1111/ajd.12452