Gender-Dependent Association of FTO Polymorphisms with Body Mass Index in Mexicans: e0145984

To evaluate the associations between six single-nucleotide polymorphisms (SNPs) in intron 1 of FTO and body mass index (BMI), a case-control association study of 2314 unrelated Mexican-Mestizo adult subjects was performed. The association between each SNP and BMI was tested using logistic and linear...

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Bibliographic Details
Published in:PloS one 2016-01, Vol.11 (1)
Main Authors: Saldana-Alvarez, Yolanda, Salas-Martinez, Maria Guadalupe, Garcia-Ortiz, Humberto, Luckie-Duque, Angelica, Garcia-Cardenas, Gustavo, Vicenteno-Ayala, Hermenegildo, Cordova, Emilio J, Esparza-Aguilar, Marcelino, Contreras-Cubas, Cecilia, Carnevale, Alessandra
Format: Article
Language:English
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Summary:To evaluate the associations between six single-nucleotide polymorphisms (SNPs) in intron 1 of FTO and body mass index (BMI), a case-control association study of 2314 unrelated Mexican-Mestizo adult subjects was performed. The association between each SNP and BMI was tested using logistic and linear regression adjusted for age, gender, and ancestry and assuming additive, recessive, and dominant effects of the minor allele. Association analysis after BMI stratification showed that all five FTO SNPs (rs1121980, rs17817449, rs3751812, rs9930506, and rs17817449), were significantly associated with obesity class II/III under an additive model (P
ISSN:1932-6203
DOI:10.1371/journal.pone.0145984