Sodium‐glucose co‐transporter (SGLT) and glucose transporter (GLUT) expression in the kidney of type 2 diabetic subjects

The sodium‐glucose co‐transporters (SGLTs) are responsible for the tubular reabsorption of filtered glucose from the kidney into the bloodstream. The inhibition of SGLT2‐mediated glucose reabsorption is a novel and highly effective strategy to alleviate hyperglycaemia in patients with type 2 diabete...

Full description

Saved in:
Bibliographic Details
Published in:Diabetes, obesity & metabolism obesity & metabolism, 2017-09, Vol.19 (9), p.1322-1326
Main Authors: Norton, Luke, Shannon, Christopher E., Fourcaudot, Marcel, Hu, Cheng, Wang, Niansong, Ren, Wei, Song, Jun, Abdul‐Ghani, Muhammad, DeFronzo, Ralph A., Ren, Jimmy, Jia, Weiping
Format: Article
Language:English
Subjects:
Adult
Biopsy
Blood Glucose - analysis
China
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - pathology
Fasting
Female
Gene Expression Regulation - drug effects
Glucose
Glucose Transporter Type 1 - genetics
Glucose Transporter Type 1 - metabolism
Glucose Transporter Type 2 - genetics
Glucose Transporter Type 2 - metabolism
glucose transporters (GLUT)
Glycated Hemoglobin A - analysis
Humans
Hypoglycemic Agents - therapeutic use
kidney
Kidney - drug effects
Kidney - metabolism
Kidney - pathology
Male
Postprandial Period
Reproducibility of Results
RNA, Messenger - metabolism
Sodium-Glucose Transporter 1 - genetics
Sodium-Glucose Transporter 1 - metabolism
Sodium-Glucose Transporter 2 - genetics
Sodium-Glucose Transporter 2 - metabolism
sodium‐glucose co‐transporters (SGLT)
type 2 diabetes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The sodium‐glucose co‐transporters (SGLTs) are responsible for the tubular reabsorption of filtered glucose from the kidney into the bloodstream. The inhibition of SGLT2‐mediated glucose reabsorption is a novel and highly effective strategy to alleviate hyperglycaemia in patients with type 2 diabetes mellitus (T2DM). However, the effectiveness of SGLT2 inhibitor therapy is diminished due, in part, to a compensatory increase in the maximum reabsorptive capacity (Tm) for glucose in patients with T2DM. We hypothesized that this increase in Tm could be explained by an increase in the tubular expression of SGLT and glucose transporters (GLUT) in these patients. To examine this, we obtained human kidney biopsy specimens from patients with or without T2DM and examined the mRNA expression of SGLTs and GLUTs. The expression of SGLT1 is markedly increased in the kidney of patients with T2DM, and SGLT1 mRNA is highly and significantly correlated with fasting and postprandial plasma glucose and HbA1c. In contrast, our data demonstrate that the levels of SGLT2 and GLUT2 mRNA are downregulated in diabetic patients, but not to a statistically significant level. These important findings are clinically significant and may have implications for the treatment of T2DM using strategies that target SGLT transporters in the kidney.
ISSN:1462-8902
1463-1326
DOI:10.1111/dom.13003