Serum levels and ApaI polymorphism of insulin-like growth factor 2 on intrauterine growth restriction infants

Purpose: The aim of our study was to evaluate the IGF2 and IGF2R plasmatic level and IGF2-ApaI polymorphism on infants with intrauterine growth restriction (IUGR). Materials and methods: A transversal study was conducted at the Neonatology Ward of the Gynecology Clinic I, Emergency Hospital Cluj-Nap...

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Published in:The journal of maternal-fetal & neonatal medicine 2018-06, Vol.31 (11), p.1470-1476
Main Authors: Hăşmăşanu, Monica G., Baizat, Melinda, Procopciuc, Lucia Maria, Blaga, Ligia, Văleanu, Mădălina A., Drugan, Tudor C., Zaharie, Gabriela C., Bolboacă, Sorana D.
Format: Article
Language:English
Subjects:
insulin-like growth factor 2 (IGF2)
insulin-like growth factor 2 receptor (IGF2R)
Intrauterine growth restriction (IUGR)
single nucleotide polymorphisms (SNPs)
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Summary:Purpose: The aim of our study was to evaluate the IGF2 and IGF2R plasmatic level and IGF2-ApaI polymorphism on infants with intrauterine growth restriction (IUGR). Materials and methods: A transversal study was conducted at the Neonatology Ward of the Gynecology Clinic I, Emergency Hospital Cluj-Napoca on neonates with IUGR who were discharged during June 2014 and June 2015. The serum levels of IGF2 and IGF2R were obtained by using ELISA method and IGF2-ApaI polymorphism by taking PCR-RFLP analysis. Results: Forty infants with IUGR and 21 infants of appropriate gestational age (AGA) were evaluated. The serum levels of IGF2 proved higher on the A/G genotype when the IUGR group was compared with AGA (p value = .048). The G allele proved significantly more frequent in both the IUGR and the AGA group compared with the A allele (p  .3). The A/G genotype proved significantly more frequent on term infants compared with preterm infants (p value = .039). Conclusions: The infant with IUGR has a higher serum level of IGF2 if has A/G IGF2-ApaI genotype and higher values of IGF2R if it has the A/A genotype.
ISSN:1476-7058
1476-4954
DOI:10.1080/14767058.2017.1319921