One Hundred Consecutive Liver Transplants Using Institutes Georges Lopez-1 Preservation Solution: Outcomes and Prognostic Factors

Abstract Background There are only 4 prior studies reporting on outcomes of liver transplantation (LT) using Institutes Georges Lopez-1 (IGL-1) preservation solution. Detection of negative predictors of LT using IGL-1 may help finding strategies to protect selected recipients at higher risk of graft...

Full description

Saved in:
Bibliographic Details
Published in:Transplantation proceedings 2017-05, Vol.49 (4), p.848-851
Main Authors: Chedid, M.F, Bosi, H.R, Chedid, A.D, Alvares-da-Silva, M.R, Leipnitz, I, Grezzana-Filho, T.J.M, Reis, M.J, Filho, G.M, Ghissi, A.J, Neto, P.R, de Araujo, A, Arruda, S, Lopes, A.B, Michalczuk, M.T, Backes, A.N, Kruel, C.D.P, Kruel, C.R.P
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
End Stage Liver Disease - surgery
Female
Graft Survival
Humans
Liver Transplantation - methods
Male
Middle Aged
Organ Preservation - methods
Organ Preservation Solutions
Postoperative Period
Prognosis
Reoperation
Retrospective Studies
Surgery
Time Factors
Warm Ischemia
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background There are only 4 prior studies reporting on outcomes of liver transplantation (LT) using Institutes Georges Lopez-1 (IGL-1) preservation solution. Detection of negative predictors of LT using IGL-1 may help finding strategies to protect selected recipients at higher risk of graft failure and death. Methods Review of all consecutive adult patients who underwent a first whole-graft LT using IGL-1 at authors' institution from 2013 to 2016. Primary end point was graft failure within the first 90 postoperative days (PODs). Graft losses due to any cause (including all deaths with a functioning graft) were recorded as graft failures. Results Of all 100 patients included in this study, 37 were women; median age was 58 years (range 18–71). There were 12 graft losses during the first 90 PODs (including 3 cases of primary nonfunction of the liver allograft), and 10 of the 12 graft losses occurred on first 30 PODs. All 12 patients who experienced graft loss (including 1 patient who underwent liver retransplantation) died within the first 90 PODs. Of the total 100 patients, 14 experienced biliary complications. Univariate analysis revealed prolonged warm ischemic time (WIT) as the only predictor of 90-day graft failure (odds ratio = 23.5, confidence interval = 1.29–430.18, P  = .03). The cutoff by receiver operating characteristic curve for WIT was 38 minutes (area under the curve = 0.70). Positive predictive value for WIT >38 minutes was 94.3%. Conclusions LT using IGL-1 can be performed safely. Similar to prior reports on LT using other preservation solutions, prolonged WIT was associated with adverse outcomes.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2017.01.061